PLEKHA8

Gene Name		pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Membrane
	Molecular Function	Glycolipid Transporter Activity Glycolipid Binding Phosphatidylinositol-4-phosphate Binding Ceramide Binding
	Biological Process	Lipid Transport Protein Transport ER To Golgi Ceramide Transport Glycolipid Transport
Pathways
Drugs
Diseases
GWAS		Estradiol levels ( 22675492)
Protein-protein Interactions		2 interactors: ARF1 CDKN2A
Entrez ID		84725
HPRD ID		10555
Ensembl ID		ENSG00000106086
Uniprot IDs		Q96JA3
PDB IDs
Enriched GO Terms of Interacting Partners?		Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Macrophage Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Cell Aging Small GTPase Mediated Signal Transduction Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Heterochromatin Assembly COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Protein Sumoylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Smooth Muscle Cell Apoptotic Process Golgi Vesicle Budding Heterochromatin Organization Regulation Of Macrophage Apoptotic Process Replicative Senescence Positive Regulation Of Signal Transduction By P53 Class Mediator Long Term Synaptic Depression Negative Regulation Of B Cell Proliferation Cellular Copper Ion Homeostasis Regulation Of Protein Sumoylation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Copper Ion Homeostasis Regulation Of Actin Nucleation Protein Destabilization Regulation Of Execution Phase Of Apoptosis Regulation Of Cellular Senescence Regulation Of Defense Response To Virus By Virus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Somatic Stem Cell Division Cellular Senescence Vesicle Targeting, To, From Or Within Golgi Regulation Of Receptor Internalization Regulation Of Protein Export From Nucleus Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Leukocyte Apoptotic Process Protein K63-linked Ubiquitination Negative Regulation Of T Cell Differentiation Regulation Of Immune System Process Retrograde Vesicle-mediated Transport, Golgi To ER Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of B Cell Activation Regulation Of Myeloid Cell Apoptotic Process Localization Within Membrane
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