COX4I2 and CYCS

Number of citations of the paper that reports this interaction (PMID 6088481)
6

Data Source:
HPRD (in vitro)

		COX4I2	CYCS
Gene Name		cytochrome c oxidase subunit IV isoform 2 (lung)	cytochrome c, somatic
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Respiratory Chain Complex IV	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain
	Molecular Function	Cytochrome-c Oxidase Activity	Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Cellular Respiration Oxidation-reduction Process Hydrogen Ion Transmembrane Transport	Response To Reactive Oxygen Species Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic DNA Fragmentation Apoptotic Process Organelle Organization Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Dephosphorylation Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Cellular Respiration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways			Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Organelle biogenesis and maintenance Detoxification of Reactive Oxygen Species Respiratory electron transport Cytochrome c-mediated apoptotic response Mitochondrial biogenesis Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response Programmed Cell Death Transcriptional activation of mitochondrial biogenesis The citric acid (TCA) cycle and respiratory electron transport Orphan transporters Intrinsic Pathway for Apoptosis
Drugs			Minocycline Protoporphyrin Ix Containing Co Heme Heme C Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		2 interactors: APP CYCS	20 interactors: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		84701	54205
HPRD ID		12143	00479
Ensembl ID		ENSG00000131055
Uniprot IDs		H6SG14 Q96KJ9	G4XXL9 P99999
PDB IDs			1J3S 3NWV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Positive Regulation Of Proteolysis Collateral Sprouting In Absence Of Injury Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Oxidative Stress Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Neuron Remodeling Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Copper Ion Homeostasis Apoptotic DNA Fragmentation Apoptotic Process Copper Ion Homeostasis Suckling Behavior Programmed Cell Death Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Apoptotic Nuclear Changes Positive Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Catalytic Activity Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Protein Tyrosine Kinase Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis	Intrinsic Apoptotic Signaling Pathway Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Alkaloid Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Cellular Respiration Cell Death Death Neuron Apoptotic Process Regulation Of Cell Death Mitochondrial Membrane Organization Response To Biotic Stimulus Neuron Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway L-ascorbic Acid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Anoikis Regulation Of Neuron Death Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Energy Derivation By Oxidation Of Organic Compounds Zymogen Activation Programmed Cell Death Respiratory Electron Transport Chain Positive Regulation Of Cell Death Regulation Of Anoikis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Biosynthetic Process Response To Metal Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Electron Transport Chain Sterol Metabolic Process Positive Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Response To Other Organism Positive Regulation Of Peptidase Activity Mitochondrion Organization Small Molecule Metabolic Process
Tagcloud ?		apaf1 bcl2l1 broaden bsp caspase3 caspase9 dazl erg eset fertility foundation foxn1 helix infertility nobox oogenesis p17 preserve renewal represses ribose seminiferous spermatogenesis spermatogonial ssc sscs suppressing tri tubules	alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling
Tagcloud (Difference) ?		apaf1 bcl2l1 broaden bsp caspase3 caspase9 dazl erg eset fertility foundation foxn1 helix infertility nobox oogenesis p17 preserve renewal represses ribose seminiferous spermatogenesis spermatogonial ssc sscs suppressing tri tubules	alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling
Tagcloud (Intersection) ?