IL1F10 and IMPDH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL1F10	IMPDH2
Description		interleukin 1 family member 10	inosine monophosphate dehydrogenase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding	Nucleotide Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Lymphocyte Proliferation Cellular Response To Interleukin-4 'de Novo' XMP Biosynthetic Process
Pathways		Interleukin-38 signaling Interleukin-36 pathway	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME
Drugs			NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874 33547301) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817 21300955 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory biomarkers ( 24182552) Interleukin-1-receptor antagonist levels ( 22205395) Interleukin-6 levels ( 33517400) Low density lipoprotein cholesterol levels ( 32154731) Myocardial infarction ( 33532862) Serum alkaline phosphatase levels ( 33547301) Stroke ( 26089329) Total cholesterol levels ( 29083408)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: IL1R1 IMPDH2	17 interacting genes: AGR2 AKT1 APIP CEBPA CLK1 CPLANE2 FXR1 FXR2 IL1F10 OGT PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4
Entrez ID		84639	3615
HPRD ID		17144	00895
Ensembl ID		ENSG00000136697	ENSG00000178035
Uniprot IDs		Q8WWZ1	A0A7I2YQK5 E7ETK5 H0Y4R1 P12268
PDB IDs		5BOW	1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ 8FOZ 8FUZ 8G8F 8G9B 9DMU
Enriched GO Terms of Interacting Partners?		Interleukin-1 Binding Smooth Muscle Adaptation Response To Peptide Positive Regulation Of Neutrophil Extravasation Regulation Of Neutrophil Extravasation Interleukin-1, Type I, Activating Receptor Activity Positive Regulation Of Interleukin-1-mediated Signaling Pathway Response To Cytokine Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Interleukin-1 Receptor Activity Positive Regulation Of T-helper 1 Cell Cytokine Production GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process IMP Dehydrogenase Activity Regulation Of Interleukin-1-mediated Signaling Pathway Platelet-derived Growth Factor Receptor Binding GMP Biosynthetic Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Positive Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Purine Ribonucleoside Monophosphate Biosynthetic Process GTP Metabolic Process Cellular Response To Interleukin-4 Interleukin-1-mediated Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Interleukin-4 GMP Metabolic Process Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Neutrophil Migration Ribonucleoside Monophosphate Biosynthetic Process Regulation Of Cellular Extravasation Regulation Of T Cell Cytokine Production Regulation Of Neutrophil Migration Nucleoside Monophosphate Biosynthetic Process Cytokine Receptor Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Peroxisomal Membrane Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Mediated Immunity Nucleoside Monophosphate Metabolic Process Response To Interleukin-1 Positive Regulation Of Cytokine Production Involved In Immune Response Immune System Process Nucleoside Triphosphate Biosynthetic Process Regulation Of T Cell Mediated Immunity Protease Binding Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Type II Interferon Production Extracellular Region	Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Translation Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Homodimerization Activity Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Gene Expression Inflammatory Response Negative Regulation Of Double-strand Break Repair Positive Regulation Of MRNA Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of DNA Repair Glutamatergic Synapse Negative Regulation Of Translational Initiation Cytokine-mediated Signaling Pathway Regulation Of Translation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA Recombination Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Sumoylation Defense Response Positive Regulation Of MRNA Metabolic Process
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