TTBK1 and CDK5R1

Number of citations of the paper that reports this interaction (PubMedID 7556643)
0

Data Source:
HPRD (in vitro)

		TTBK1	CDK5R1
Description		tau tubulin kinase 1	cyclin dependent kinase 5 regulatory subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Microtubule Cytoskeleton Neuronal Cell Body Perinuclear Region Of Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Contractile Muscle Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Protease Binding Actin Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Signal Transduction Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Substantia Nigra Development Positive Regulation Of Protein Polymerization Positive Regulation Of Astrocyte Activation Positive Regulation Of Microglial Cell Activation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Cerebral Cortex Radially Oriented Cell Migration Layer Formation In Cerebral Cortex Neuron Differentiation Positive Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis G1 To G0 Transition Involved In Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways			CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes
Drugs			Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS		Adult hearing difficulty ( 31564434) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 29403010) Pulse pressure ( 28739976) Red blood cell count ( 32888494) Systolic blood pressure ( 26390057 28739976 29403010)
Interacting Genes		5 interacting genes: CDK5R1 CSN1S1 MAP2 MAPT TUBB	35 interacting genes: ACTN1 AMPH APP BCL2L13 BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 FEM1B FEM1C HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		84630	8851
HPRD ID		11653	04586
Ensembl ID		ENSG00000146216	ENSG00000176749
Uniprot IDs		Q5TCY1	Q15078 Q8N619
PDB IDs		4BTJ 4BTK 4BTM 4NFM 4NFN 7JXX 7JXY 7Q8V 7Q8W 7QHW 7ZHN 7ZHO 7ZHP 7ZHQ 8XPZ 9HHW	1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG 7VDP 7VDQ 7VDR 7VDS
Enriched GO Terms of Interacting Partners?		Main Axon Regulation Of Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Microtubule-based Process Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Polymerization Cytoskeleton Organization Microtubule Central Nervous System Neuron Development Neuron Projection Neuronal Cell Body Regulation Of Supramolecular Fiber Organization Tubulin Binding Regulation Of Neuron Projection Development Regulation Of Protein-containing Complex Assembly Response To 11-deoxycorticosterone Neuron Projection Development Regulation Of Cytoskeleton Organization Regulation Of Axon Extension Dendrite Apical Distal Dendrite Histone-dependent DNA Binding Positive Regulation Of Protein Polymerization Cell Body Cytoplasmic Ribonucleoprotein Granule Tubulin Complex Microtubule Lateral Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite Regulation Of Cell Projection Organization Neurofibrillary Tangle Assembly Superior Olivary Nucleus Maturation Growth Cone Regulation Of Axonogenesis Dendritic Spine Response To Dehydroepiandrosterone Proximal Neuron Projection Dendritic Branch Protein Kinase 5 Complex Positive Regulation Of Supramolecular Fiber Organization Neuron Development Structural Molecule Activity Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Vesicle Transport Along Microtubule	Regulation Of Apoptotic Process Cytoplasm Developmental Process Cytosol Regulation Of Programmed Cell Death Positive Regulation Of Protein Polymerization Receptor Metabolic Process Acetylcholine Receptor Activator Activity Protein Kinase Binding Neurofibrillary Tangle Assembly Neuron Projection Development Protein Serine Kinase Activity Receptor Catabolic Process Developmental Growth Involved In Morphogenesis Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Developmental Process Perinuclear Region Of Cytoplasm Regulation Of Protein Localization Programmed Cell Death Cell Death Protein Serine/threonine Kinase Activity Establishment Of Organelle Localization Calpain Complex Cyclin-dependent Protein Serine/threonine Kinase Activity Amyloid Fibril Formation Cellular Developmental Process Regulation Of Neurotransmitter Secretion Main Axon Vesicle-mediated Transport In Synapse Positive Regulation Of Microtubule Polymerization Dendrite Organelle Localization Cell Differentiation Establishment Of Localization In Cell Regulation Of Cell Differentiation Synaptic Vesicle Transport NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Cell Projection Organization Establishment Of Vesicle Localization Synaptic Vesicle Endocytosis Protein Kinase Activity Neuron Apoptotic Process Neuronal Cell Body Presynaptic Endocytosis Tau Protein Binding Oligodendrocyte Differentiation Developmental Cell Growth
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