TTBK1 and MAP2

Number of citations of the paper that reports this interaction (PubMedID 7556643)
0

Data Source:
HPRD (in vitro)

		TTBK1	MAP2
Description		tau tubulin kinase 1	microtubule associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Microtubule Cytoskeleton Neuronal Cell Body Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Cilium Dendrite Dendrite Cytoplasm Cell Projection Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Tau Protein Binding
	Biological Process	Signal Transduction Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Substantia Nigra Development Positive Regulation Of Protein Polymerization Positive Regulation Of Astrocyte Activation Positive Regulation Of Microglial Cell Activation	Microtubule Cytoskeleton Organization Dendrite Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Protein Localization Dendrite Morphogenesis Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport
Pathways
Drugs			Estramustine Paclitaxel Docetaxel
Diseases
GWAS		Adult hearing difficulty ( 31564434) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 29403010) Pulse pressure ( 28739976) Red blood cell count ( 32888494) Systolic blood pressure ( 26390057 28739976 29403010)	Adventurousness ( 30643258) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Handedness (Left-handed vs. non-left-handed) ( 30980028 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Skin and soft tissue infections ( 33662382) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: CDK5R1 CSN1S1 MAP2 MAPT TUBB	26 interacting genes: ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D ITCH JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 YAP1
Entrez ID		84630	4133
HPRD ID		11653	01140
Ensembl ID		ENSG00000146216	ENSG00000078018
Uniprot IDs		Q5TCY1	A0A024R3Z1 P11137 Q6NYC5
PDB IDs		4BTJ 4BTK 4BTM 4NFM 4NFN 7JXX 7JXY 7Q8V 7Q8W 7QHW 7ZHN 7ZHO 7ZHP 7ZHQ 8XPZ 9HHW
Enriched GO Terms of Interacting Partners?		Main Axon Regulation Of Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Microtubule-based Process Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Polymerization Cytoskeleton Organization Microtubule Central Nervous System Neuron Development Neuron Projection Neuronal Cell Body Regulation Of Supramolecular Fiber Organization Tubulin Binding Regulation Of Neuron Projection Development Regulation Of Protein-containing Complex Assembly Response To 11-deoxycorticosterone Neuron Projection Development Regulation Of Cytoskeleton Organization Regulation Of Axon Extension Dendrite Apical Distal Dendrite Histone-dependent DNA Binding Positive Regulation Of Protein Polymerization Cell Body Cytoplasmic Ribonucleoprotein Granule Tubulin Complex Microtubule Lateral Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite Regulation Of Cell Projection Organization Neurofibrillary Tangle Assembly Superior Olivary Nucleus Maturation Growth Cone Regulation Of Axonogenesis Dendritic Spine Response To Dehydroepiandrosterone Proximal Neuron Projection Dendritic Branch Protein Kinase 5 Complex Positive Regulation Of Supramolecular Fiber Organization Neuron Development Structural Molecule Activity Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Vesicle Transport Along Microtubule	Tau Protein Binding Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Tau-protein Kinase Activity Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Protein Domain Specific Binding Anatomical Structure Morphogenesis Glutamatergic Synapse Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Synapse Organization Positive Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Dendrite Phospholipase Binding Developmental Process Supramolecular Fiber Organization Regulation Of Developmental Process System Process Ephrin Receptor Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Response To Hormone Cytoplasm Plasma Membrane Regulation Of Cell Activation Response To Peptide Hormone Regulation Of Endocytosis Positive Regulation Of Cellular Component Organization Nervous System Process Cellular Component Assembly Negative Regulation Of Signal Transduction Extracellular Exosome Cell-cell Junction Regulation Of Cellular Localization Cytosol Protein-containing Complex Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Dendritic Spine Maintenance Cellular Response To Amyloid-beta Glutamate Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Protein Catabolic Process Regulation Of Cell Differentiation Regulation Of System Process Regulation Of Neuronal Synaptic Plasticity
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