TTBK1

Description		tau tubulin kinase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Microtubule Cytoskeleton Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Substantia Nigra Development Positive Regulation Of Protein Polymerization Positive Regulation Of Astrocyte Activation Positive Regulation Of Microglial Cell Activation
Pathways
Drugs
Diseases
GWAS		Adult hearing difficulty ( 31564434) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 29403010) Pulse pressure ( 28739976) Red blood cell count ( 32888494) Systolic blood pressure ( 26390057 28739976 29403010)
Interacting Genes		5 interacting genes: CDK5R1 CSN1S1 MAP2 MAPT TUBB
Entrez ID		84630
HPRD ID		11653
Ensembl ID		ENSG00000146216
Uniprot IDs		Q5TCY1
PDB IDs		4BTJ 4BTK 4BTM 4NFM 4NFN 7JXX 7JXY 7Q8V 7Q8W 7QHW 7ZHN 7ZHO 7ZHP 7ZHQ 8XPZ 9HHW
Enriched GO Terms of Interacting Partners?		Main Axon Regulation Of Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Microtubule-based Process Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Polymerization Cytoskeleton Organization Microtubule Central Nervous System Neuron Development Neuron Projection Neuronal Cell Body Regulation Of Supramolecular Fiber Organization Tubulin Binding Regulation Of Neuron Projection Development Regulation Of Protein-containing Complex Assembly Response To 11-deoxycorticosterone Neuron Projection Development Regulation Of Cytoskeleton Organization Regulation Of Axon Extension Dendrite Apical Distal Dendrite Histone-dependent DNA Binding Positive Regulation Of Protein Polymerization Cell Body Cytoplasmic Ribonucleoprotein Granule Tubulin Complex Microtubule Lateral Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite Regulation Of Cell Projection Organization Neurofibrillary Tangle Assembly Superior Olivary Nucleus Maturation Growth Cone Regulation Of Axonogenesis Dendritic Spine Response To Dehydroepiandrosterone Proximal Neuron Projection Dendritic Branch Protein Kinase 5 Complex Positive Regulation Of Supramolecular Fiber Organization Neuron Development Structural Molecule Activity Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Vesicle Transport Along Microtubule
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