CMKLR1 and TPST2

Number of citations of the paper that reports this interaction (PubMedID 17558413)
0

Data Source:
HPRD (in vitro)

		CMKLR1	TPST2
Description		chemerin chemokine-like receptor 1	tyrosylprotein sulfotransferase 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane
	Molecular Function	Complement Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Signaling Receptor Activity Adipokinetic Hormone Receptor Activity Adipokinetic Hormone Binding	Protein-tyrosine Sulfotransferase Activity Transferase Activity Protein Homodimerization Activity
	Biological Process	Skeletal System Development Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Immune Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Macrophage Chemotaxis Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-12 Production Positive Regulation Of Fat Cell Differentiation Regulation Of Calcium-mediated Signaling Chemokine-mediated Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Peptidyl-tyrosine Sulfation Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Prevention Of Polyspermy
Pathways		Class A/1 (Rhodopsin-like receptors)	Cytosolic sulfonation of small molecules Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Defective F8 sulfation at Y1699 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 22688191) Erectile dysfunction and prostate cancer treatment ( 20932654) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Protein level change in low calorie diet obesity intervention ( 29234017) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 21483023) Risk-taking tendency (4-domain principal component model) ( 30643258)	Anti-saccade response ( 29064472) Blood protein levels ( 30072576) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: TPST1 TPST2	7 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GOLPH3 GOLPH3L SELPLG
Entrez ID		1240	8459
HPRD ID		03829	07217
Ensembl ID		ENSG00000174600	ENSG00000128294
Uniprot IDs		Q99788	O60704
PDB IDs		7YKD 8SG1 8ZJG 9L3W	3AP1 3AP2 3AP3
Enriched GO Terms of Interacting Partners?		Protein-tyrosine Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Peptidyl-tyrosine Sulfation Trans-Golgi Network Sulfur Compound Metabolic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Metabolic Process Protein Sulfation Nucleotide Metabolic Process Prevention Of Polyspermy Purine-containing Compound Metabolic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Fertilization Golgi Membrane Protein Homodimerization Activity Organic Acid Metabolic Process Carbohydrate Derivative Metabolic Process Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sulfation Plasma Membrane Fusion Organophosphate Metabolic Process Phosphate-containing Compound Metabolic Process Golgi Apparatus Small Molecule Metabolic Process Negative Regulation Of Reproductive Process Protein Modification Process Transferase Activity Plasma Membrane Organization Membrane Fusion Regulation Of Reproductive Process Nucleobase-containing Compound Metabolic Process Protein Metabolic Process	Chemokine Receptor Activity Adipokinetic Hormone Binding Adipokinetic Hormone Receptor Activity Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Chemokine-mediated Signaling Pathway Golgi Cisterna G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Leukocyte Tethering Or Rolling C-C Chemokine Binding C-C Chemokine Receptor Activity Leukocyte Adhesion To Vascular Endothelial Cell Phosphatidylinositol-4-phosphate Binding Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport G Protein-coupled Receptor Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Cell Adhesion Cell Migration Chemotaxis Leukocyte Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Locomotion Golgi Cisterna Membrane Cell Motility Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Chemokine (C-C Motif) Ligand 5 Binding Chemokine (C-C Motif) Ligand 7 Binding Leukocyte Adhesive Activation Post-Golgi Vesicle-mediated Transport Asymmetric Golgi Ribbon Formation Golgi Organization Response To Cytokine Response To Peptide Cell Adhesion Molecule Production Cellular Response To Rapamycin Vesicle-mediated Transport To The Plasma Membrane Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Protein Secretion Positive Regulation Of Leukocyte Migration Signaling Membrane Protein Retention In Golgi Apparatus
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