CMKLR1

Description		chemerin chemokine-like receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Complement Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Signaling Receptor Activity Adipokinetic Hormone Receptor Activity Adipokinetic Hormone Binding
	Biological Process	Skeletal System Development Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Immune Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Macrophage Chemotaxis Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-12 Production Positive Regulation Of Fat Cell Differentiation Regulation Of Calcium-mediated Signaling Chemokine-mediated Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Class A/1 (Rhodopsin-like receptors)
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 22688191) Erectile dysfunction and prostate cancer treatment ( 20932654) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Protein level change in low calorie diet obesity intervention ( 29234017) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 21483023) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		2 interacting genes: TPST1 TPST2
Entrez ID		1240
HPRD ID		03829
Ensembl ID		ENSG00000174600
Uniprot IDs		Q99788
PDB IDs		7YKD 8SG1 8ZJG 9L3W
Enriched GO Terms of Interacting Partners?		Protein-tyrosine Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Peptidyl-tyrosine Sulfation Trans-Golgi Network Sulfur Compound Metabolic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Metabolic Process Protein Sulfation Nucleotide Metabolic Process Prevention Of Polyspermy Purine-containing Compound Metabolic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Fertilization Golgi Membrane Protein Homodimerization Activity Organic Acid Metabolic Process Carbohydrate Derivative Metabolic Process Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sulfation Plasma Membrane Fusion Organophosphate Metabolic Process Phosphate-containing Compound Metabolic Process Golgi Apparatus Small Molecule Metabolic Process Negative Regulation Of Reproductive Process Protein Modification Process Transferase Activity Plasma Membrane Organization Membrane Fusion Regulation Of Reproductive Process Nucleobase-containing Compound Metabolic Process Protein Metabolic Process
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