CUL2 and CREM

		CUL2	CREM
Description		cullin 2	cAMP responsive element modulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Lumen	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Membrane ATF4-CREB1 Transcription Factor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Glycosphingolipid Metabolic Process Signal Transduction Spermatogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process CAMP/PKA Signal Transduction
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		28 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 GPS1 KAT2A KHNYN MKNK2 NEDD8 RNF7 SAP130 SENP8 TRIP12 UBC UBE2D1 UBE2D3 UBE2M VHL ZER1 ZYG11B	45 interacting genes: ATF1 ATXN1 BHLHE40 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 DNMT3L EMP3 FHL5 GLIS2 GSK3A GSK3B HDAC1 HPCA HPCAL1 KCNIP3 MAPK3 MKNK1 MYOZ3 NCALD NCS1 PIAS3 POU2F1 PRKACA PRKCA RHOXF2 ROR2 RUSC1 SNRPB SNRPC SP100 SPI1 TAF4 TBP UBAP2 UBE2I VENTX
Entrez ID		8453	1390
HPRD ID		06786	00444
Ensembl ID		ENSG00000108094	ENSG00000095794
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 A0A8I5KVR3 B7Z1Y1 Q13617	E9PAR2 E9PB41 Q03060
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 7PLO 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8PQL 8Q7R 8QU8 8R5H 8RWZ 8RX0 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH
Enriched GO Terms of Interacting Partners?		Protein Neddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Protein Neddylation Protein Modification Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Metabolic Process Cullin Family Protein Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Proteolysis Cul2-RING Ubiquitin Ligase Complex Regulation Of Primary Metabolic Process Ubiquitin Ligase Complex Nucleus Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Binding Regulation Of Macromolecule Metabolic Process Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Protein Modification Process Nucleoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process DeNEDDylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity	Nucleus Regulation Of Transcription By RNA Polymerase II Protein Serine Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Kinase Activity Protein Serine/threonine Kinase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Gene Expression Kinase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Protein Modification Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Protein Localization Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Transferase Activity CAMP/PKA Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction ATP Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition
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