CREM and CASP8AP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CREM	CASP8AP2
Description		cAMP responsive element modulator	caspase 8 associated protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Membrane ATF4-CREB1 Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Glycosphingolipid Metabolic Process Signal Transduction Spermatogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process CAMP/PKA Signal Transduction	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Negative Regulation Of DNA-templated Transcription Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway
Pathways			SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 23128233 28067908)	Asthma ( 31959851) Estimated glomerular filtration rate in non-diabetics ( 31451708) Femur bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602)
Interacting Genes		45 interacting genes: ATF1 ATXN1 BHLHE40 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 DNMT3L EMP3 FHL5 GLIS2 GSK3A GSK3B HDAC1 HPCA HPCAL1 KCNIP3 MAPK3 MKNK1 MYOZ3 NCALD NCS1 PIAS3 POU2F1 PRKACA PRKCA RHOXF2 ROR2 RUSC1 SNRPB SNRPC SP100 SPI1 TAF4 TBP UBAP2 UBE2I VENTX	21 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL KLHL20 MX1 NAA10 NR3C2 PML RAD51 SP100 SREBF2 TCL1A TRAF2 TRIM21 UBE2I
Entrez ID		1390	9994
HPRD ID		00444	06048
Ensembl ID		ENSG00000095794	ENSG00000118412
Uniprot IDs		E9PAR2 E9PB41 Q03060	Q9UKL3
PDB IDs			2LR8 6ANO 6AOZ 6AP0
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Protein Serine Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Kinase Activity Protein Serine/threonine Kinase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Gene Expression Kinase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Protein Modification Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Protein Localization Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Transferase Activity CAMP/PKA Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction ATP Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition	CD95 Death-inducing Signaling Complex Death Effector Domain Binding Ripoptosome Positive Regulation Of Signal Transduction Death-inducing Signaling Complex Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Identical Protein Binding PML Body Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Execution Phase Of Apoptosis Response To Cytokine Cytoplasm Response To Peptide Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Nucleus TRAIL-activated Apoptotic Signaling Pathway Apoptotic Process Signal Transduction Cell Death Response To Stress Programmed Cell Death Regulation Of Apoptotic Signaling Pathway N-terminal Protein Amino Acid Acetylation Response To Type I Interferon Cellular Response To Mechanical Stimulus Positive Regulation Of Biosynthetic Process Negative Regulation Of Viral Process Cell Body Motor Neuron Apoptotic Process Negative Regulation Of RNA Metabolic Process
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