HSD17B7 and CA1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HSD17B7	CA1
Description		hydroxysteroid 17-beta dehydrogenase 7	carbonic anhydrase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity	Arylesterase Activity Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Lyase Activity Hydro-lyase Activity Cyanamide Hydratase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Estrogen Biosynthetic Process Nervous System Development Brain Development Androgen Metabolic Process Cell Differentiation Embryonic Organ Development Embryonic Skeletal System Development	Response To Fructose
Pathways		Cholesterol biosynthesis Cholesterol biosynthesis via lathosterol	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		NADH	Methyclothiazide Topiramate Chlorthalidone Ethoxzolamide Amlodipine Methocarbamol Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Trichlormethiazide Ethinamate Diazoxide Diclofenamide Brinzolamide Quinethazone N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE Ellagic acid Sodium carbonate Sodium sulfate
Diseases
GWAS		Dupuytren's disease ( 28886342)	Blood protein levels ( 30072576) Blood trace element (Zn levels) ( 23720494) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Zinc levels ( 26025379)
Interacting Genes		6 interacting genes: BRSK1 CA1 DTYMK GORAB GPAT4 VKORC1	3 interacting genes: HSD17B7 MAPK6 TFCP2
Entrez ID		51478	759
HPRD ID		05996	00265
Ensembl ID		ENSG00000132196	ENSG00000133742
Uniprot IDs		P56937	P00915 V9HWE3
PDB IDs			1AZM 1BZM 1CRM 1CZM 1HCB 1HUG 1HUH 1J9W 1JV0 2CAB 2FOY 2FW4 2IT4 2NMX 2NN1 2NN7 3LXE 3W6H 3W6I 4WR7 4WUP 4WUQ 5E2M 5GMM 6EVR 6EX1 6F3B 6FAF 6FAG 6G3V 6HWZ 6I0J 6I0L 6SWM 6XZE 6XZO 6XZS 6XZX 6XZY 6Y00 7PLF 7Q0D 7QOB 7ZL5 8CDX 8CDZ 8Q6L 8Q7G 8QGV 8QQ9 8QUN 8RLO 8S4F
Enriched GO Terms of Interacting Partners?		DTMP Kinase Activity DUDP Biosynthetic Process DTDP Biosynthetic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Cyanamide Hydratase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glycerol-3-phosphate O-acyltransferase Activity Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Distal Axon Arylesterase Activity Thymidine Biosynthetic Process DTTP Biosynthetic Process Synaptic Vesicle Cycle Hydro-lyase Activity Thymidine Metabolic Process Pyrimidine Deoxyribonucleotide Biosynthetic Process Regulation Of Synaptic Vesicle Clustering Glandular Epithelial Cell Maturation Response To Fructose Quinone Binding Regulation Of Synaptic Vesicle Priming Cholinergic Synapse Lysophosphatidic Acid Acyltransferase Activity CDP-diacylglycerol Biosynthetic Process Columnar/cuboidal Epithelial Cell Maturation Carbonate Dehydratase Activity Pyrimidine Nucleoside Metabolic Process 2'-deoxyribonucleotide Biosynthetic Process Nucleoside Diphosphate Kinase Activity Deoxyribonucleotide Biosynthetic Process Nucleoside Diphosphate Biosynthetic Process RSC-type Complex Peptidyl-glutamic Acid Modification Regulation Of Body Fluid Levels Vitamin K Metabolic Process CDP-diacylglycerol Metabolic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Biosynthetic Process	Septin Cytoskeleton 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?