HSD17B7 and DTYMK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HSD17B7	DTYMK
Description		hydroxysteroid 17-beta dehydrogenase 7	deoxythymidylate kinase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity	Nucleotide Binding Nucleoside Diphosphate Kinase Activity DTMP Kinase Activity ATP Binding Kinase Activity Transferase Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Estrogen Biosynthetic Process Nervous System Development Brain Development Androgen Metabolic Process Cell Differentiation Embryonic Organ Development Embryonic Skeletal System Development	DUDP Biosynthetic Process DTDP Biosynthetic Process DTTP Biosynthetic Process Nucleotide Biosynthetic Process Thymidine Biosynthetic Process Cellular Response To Growth Factor Stimulus
Pathways		Cholesterol biosynthesis Cholesterol biosynthesis via lathosterol	Interconversion of nucleotide di- and triphosphates
Drugs		NADH	Thymidine monophosphate 2',3'-Dideoxythymidine-5'-Monophosphate 3'-Fluoro-3'-deoxythymidine 5'-monophosphate 3'-deoxy-3'-aminothymidine monophosphate p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate Zidovudine monophosphate P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Dupuytren's disease ( 28886342)	Asthma ( 31959851) Diverticular disease ( 30177863) Prostate cancer ( 23535732)
Interacting Genes		6 interacting genes: BRSK1 CA1 DTYMK GORAB GPAT4 VKORC1	4 interacting genes: CDC20 CEBPA FZR1 HSD17B7
Entrez ID		51478	1841
HPRD ID		05996	01773
Ensembl ID		ENSG00000132196	ENSG00000168393
Uniprot IDs		P56937	P23919 Q53F55 Q6FGU2
PDB IDs			1E2D 1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1NMX 1NMY 1NMZ 1NN0 1NN1 1NN3 1NN5 2XX3
Enriched GO Terms of Interacting Partners?		DTMP Kinase Activity DUDP Biosynthetic Process DTDP Biosynthetic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Cyanamide Hydratase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glycerol-3-phosphate O-acyltransferase Activity Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Distal Axon Arylesterase Activity Thymidine Biosynthetic Process DTTP Biosynthetic Process Synaptic Vesicle Cycle Hydro-lyase Activity Thymidine Metabolic Process Pyrimidine Deoxyribonucleotide Biosynthetic Process Regulation Of Synaptic Vesicle Clustering Glandular Epithelial Cell Maturation Response To Fructose Quinone Binding Regulation Of Synaptic Vesicle Priming Cholinergic Synapse Lysophosphatidic Acid Acyltransferase Activity CDP-diacylglycerol Biosynthetic Process Columnar/cuboidal Epithelial Cell Maturation Carbonate Dehydratase Activity Pyrimidine Nucleoside Metabolic Process 2'-deoxyribonucleotide Biosynthetic Process Nucleoside Diphosphate Kinase Activity Deoxyribonucleotide Biosynthetic Process Nucleoside Diphosphate Biosynthetic Process RSC-type Complex Peptidyl-glutamic Acid Modification Regulation Of Body Fluid Levels Vitamin K Metabolic Process CDP-diacylglycerol Metabolic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Biosynthetic Process	Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Nuclear Division Alcohol Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Meiotic Cell Cycle Small Molecule Biosynthetic Process Small Molecule Metabolic Process Regulation Of Protein Metabolic Process Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Positive Regulation Of Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Protein Ubiquitination Cholesterol Metabolic Process Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Sterol Metabolic Process Regeneration Response To Vitamin B2 C/EBP Complex Dihydrofolate Reductase Activity Regulation Of Nuclear Division CHOP-C/EBP Complex Embryonic Organ Development Dihydrofolate Metabolic Process DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Metabolic Process Meiotic Cell Cycle Phase Transition
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