HSD17B7 and GPAT4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HSD17B7	GPAT4
Description		hydroxysteroid 17-beta dehydrogenase 7	glycerol-3-phosphate acyltransferase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Glycerol-3-phosphate O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Estrogen Biosynthetic Process Nervous System Development Brain Development Androgen Metabolic Process Cell Differentiation Embryonic Organ Development Embryonic Skeletal System Development	Glandular Epithelial Cell Maturation Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Triglyceride Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylcholine Biosynthetic Process Lactation Lipid Biosynthetic Process Phospholipid Biosynthetic Process CDP-diacylglycerol Biosynthetic Process Triglyceride Biosynthetic Process Mammary Gland Development Regulation Of Multicellular Organism Growth Diacylglycerol Metabolic Process
Pathways		Cholesterol biosynthesis Cholesterol biosynthesis via lathosterol	Synthesis of PA
Drugs		NADH
Diseases
GWAS		Dupuytren's disease ( 28886342)
Interacting Genes		6 interacting genes: BRSK1 CA1 DTYMK GORAB GPAT4 VKORC1	2 interacting genes: GFI1B HSD17B7
Entrez ID		51478	137964
HPRD ID		05996	12175
Ensembl ID		ENSG00000132196	ENSG00000158669
Uniprot IDs		P56937	Q86UL3
PDB IDs
Enriched GO Terms of Interacting Partners?		DTMP Kinase Activity DUDP Biosynthetic Process DTDP Biosynthetic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Cyanamide Hydratase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glycerol-3-phosphate O-acyltransferase Activity Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Distal Axon Arylesterase Activity Thymidine Biosynthetic Process DTTP Biosynthetic Process Synaptic Vesicle Cycle Hydro-lyase Activity Thymidine Metabolic Process Pyrimidine Deoxyribonucleotide Biosynthetic Process Regulation Of Synaptic Vesicle Clustering Glandular Epithelial Cell Maturation Response To Fructose Quinone Binding Regulation Of Synaptic Vesicle Priming Cholinergic Synapse Lysophosphatidic Acid Acyltransferase Activity CDP-diacylglycerol Biosynthetic Process Columnar/cuboidal Epithelial Cell Maturation Carbonate Dehydratase Activity Pyrimidine Nucleoside Metabolic Process 2'-deoxyribonucleotide Biosynthetic Process Nucleoside Diphosphate Kinase Activity Deoxyribonucleotide Biosynthetic Process Nucleoside Diphosphate Biosynthetic Process RSC-type Complex Peptidyl-glutamic Acid Modification Regulation Of Body Fluid Levels Vitamin K Metabolic Process CDP-diacylglycerol Metabolic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Biosynthetic Process	Estrogen Biosynthetic Process 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Kynurenine Metabolic Process L-tryptophan Catabolic Process To Kynurenine Indoleamine 2,3-dioxygenase Activity L-tryptophan Catabolic Process Tryptophan 2,3-dioxygenase Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity L-tryptophan Metabolic Process Androgen Metabolic Process Steroid Hormone Biosynthetic Process NAD+ Biosynthetic Process Benzene-containing Compound Metabolic Process Aromatic Amino Acid Family Catabolic Process Pyridine Nucleotide Biosynthetic Process Estrogen Metabolic Process Hormone Biosynthetic Process Cholesterol Biosynthetic Process Aromatic Amino Acid Metabolic Process Sterol Biosynthetic Process NAD+ Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?