CTH

Gene Name		cystathionine gamma-lyase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Carbon-sulfur Lyase Activity Pyridoxal Phosphate Binding L-cystine L-cysteine-lyase (deaminating) Homocysteine Desulfhydrase Activity L-cysteine Desulfhydrase Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Cellular Nitrogen Compound Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Protein Sulfhydration Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Degradation of cysteine and homocysteine Sulfur amino acid metabolism Cysteine formation from homocysteine Metabolism of amino acids and derivatives
Drugs		Pyridoxal Phosphate L-Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases
GWAS
Protein-protein Interactions		4 interactors: GUCD1 RECK SDCBP2 WDYHV1
Entrez ID		1491
HPRD ID		09633
Ensembl ID		ENSG00000116761
Uniprot IDs		P32929
PDB IDs		2NMP 3COG 3ELP
Enriched GO Terms of Interacting Partners?
Tagcloud ?		additionally allows cbs contribution cystathionase cystathionine cysteine determination employed evaluating gamma glutathione gsh gssg h2s homogenates homoserine hplc inhibiting ketobutyrate measure propargylglycine reactions redox reflect rp synthase totally undertaken