CTH

Description		cystathionine gamma-lyase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding L-cystine L-cysteine-lyase (deaminating) Homocysteine Desulfhydrase Activity L-cysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity
	Biological Process	Cysteine Metabolic Process Lipid Metabolic Process Amino Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Sulfhydration Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs		Pyridoxal phosphate Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases		Cystathioninuria
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Brain volume in infants (grey matter) ( 28763065) Declining hemoglobin trajectory in blood donors ( 33491795) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Seasonality and depression ( 30217971)
Novel Interacting Genes		1 novel interacting genes: PTGFR
Interacting Genes		4 interacting genes: GUCD1 NTAQ1 RECK SDCBP2
Entrez ID		1491
HPRD ID		09633
Ensembl ID		ENSG00000116761
Uniprot IDs		P32929
PDB IDs		2NMP 3COG 3ELP 5EIG 5TSU 5TT2 6NBA 6OVG
Enriched GO Terms of Interacting Partners?		Prostaglandin F Receptor Activity Protein-N-terminal Glutamine Amidohydrolase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Establishment Of Blood-brain Barrier
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