SIGMAR1 and ANK2

Number of citations of the paper that reports this interaction (PMID 11149946)
50

Data Source:
HPRD (in vivo, in vitro)

		SIGMAR1	ANK2
Gene Name		sigma non-opioid intracellular receptor 1	ankyrin 2, neuronal
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Membrane Lipid Particle Integral Component Of Plasma Membrane Integral Component Of Membrane Cell Junction Growth Cone	Intracellular Cytosol Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Opioid Receptor Activity Drug Binding	Structural Constituent Of Cytoskeleton Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding ATPase Binding
	Biological Process	Lipid Transport Nervous System Development Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis Axon Guidance Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Protein Targeting To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Membrane Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity
Pathways			Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs		Dextromethorphan Naltrexone
Diseases
GWAS			Blood trace element (Cu levels) ( 23720494) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		3 interactors: ANK2 ITPR3 PDZD11	12 interactors: DNAJB1 EPB42 KIAA0368 L1CAM NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53
Entrez ID		10280	287
HPRD ID		03580	00110
Ensembl ID		ENSG00000147955	ENSG00000145362
Uniprot IDs		A2A3U5 B4DR71 Q99720	Q01484
PDB IDs			4D8O
Enriched GO Terms of Interacting Partners?		Second-messenger-mediated Signaling Protein Localization To Plasma Membrane Protein Localization To T-tubule Protein Localization To M-band T-tubule Organization Plasma Membrane Organization Ion Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Calcium Ion Transport Protein Localization To Basolateral Plasma Membrane Membrane Depolarization During SA Node Cell Action Potential Establishment Of Localization In Cell SA Node Cell Action Potential Maintenance Of Epithelial Cell Apical/basal Polarity Sensory Perception Of Sweet Taste Protein Localization To Membrane Maintenance Of Apical/basal Cell Polarity Sensory Perception Of Umami Taste Cellular Metal Ion Homeostasis Regulation Of Cardiac Muscle Cell Membrane Potential Endomembrane System Organization Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication Atrial Cardiac Muscle Cell To AV Node Cell Communication Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Localization Response To Methylmercury Metal Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Pantothenate Metabolic Process Maintenance Of Cell Polarity Biotin Metabolic Process Cellular Chemical Homeostasis Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ion Homeostasis Cell-cell Signaling Involved In Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transport Paranodal Junction Assembly Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Inositol Phosphate-mediated Signaling Protein Localization To Cell Surface Ventricular Cardiac Muscle Cell Action Potential Cellular Homeostasis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Atrial Septum Development Regulation Of Heart Rate By Cardiac Conduction	Regulation Of Cellular Component Organization Regulation Of Cell Growth Membrane Organization Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Morphogenesis Neurogenesis Anatomical Structure Development Regulation Of Intracellular Signal Transduction Axonogenesis Cell Morphogenesis Cell Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Component Assembly Cell Projection Organization Regulation Of Growth Developmental Process Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Morphogenesis System Development Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Size Regulation Of Axon Extension Neuron Projection Development Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Regulation Of Neuron Projection Development Axon Guidance Neuron Development Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Endomembrane System Organization Regulation Of Signal Transduction B Cell Differentiation Negative Regulation Of Helicase Activity Protein Localization To M-band Positive Regulation Of Cell Growth Regulation Of Cell Projection Organization Protein Import Into Nucleus Protein Localization Protein Metabolic Process Nuclear Import Neuron Differentiation
Tagcloud ?		became chaperones chronologically cytoplasm degrades epoxomicin exportin harboring hela huntingtin huntington inclusion inclusions insolubilized lc3 leptomycin machinery misfolded ni nis nucleus p62 participate polyglutamine proteasome shuttle sirna unchanged	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Difference) ?		became chaperones chronologically cytoplasm degrades epoxomicin exportin harboring huntingtin huntington inclusion inclusions insolubilized lc3 leptomycin machinery misfolded ni nis nucleus p62 participate polyglutamine proteasome shuttle sirna unchanged	absent eif2alpha encode failed indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Intersection) ?		hela