RPAIN and ADH6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RPAIN	ADH6
Gene Name		RPA interacting protein	alcohol dehydrogenase 6 (class V)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm PML Body	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Complex Binding Metal Ion Binding	Alcohol Dehydrogenase (NAD) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Zinc Ion Binding Ethanol Binding
	Biological Process	DNA-dependent DNA Replication DNA Repair DNA Recombination Protein Import Into Nucleus Response To UV	Ethanol Oxidation Xenobiotic Metabolic Process Small Molecule Metabolic Process Response To Ethanol
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Ethanol oxidation Metabolic disorders of biological oxidation enzymes Defective CYP1B1 causes Glaucoma Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations
Drugs
Diseases
GWAS			Alcohol dependence ( 23456092) Esophageal cancer ( 19698717) QRS duration ( 23534349)
Protein-Protein Interactions		4 interactors: ADH6 CDCA5 CYP17A1 GSTA1	8 interactors: ANKRD17 ARRB1 KRAS RASSF5 RPAIN RPS29 RSL1D1 TNIP1
Entrez ID		84268	130
HPRD ID		14615	00067
Ensembl ID		ENSG00000129197	ENSG00000172955
Uniprot IDs		B3KTT3 E9PDG9 Q86UA6	E9PBI1 P28332 Q8IUN7
PDB IDs
Enriched GO Terms of Interacting Partners?		Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Response To Acetate Regulation Of Cohesin Localization To Chromatin Alcohol Metabolic Process Response To Fungicide Phthalate Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Response To Herbicide Response To Methylmercury Dibenzo-p-dioxin Metabolic Process Biphenyl Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Mitotic Sister Chromatid Cohesion Ethanol Oxidation Regulation Of Sister Chromatid Cohesion Androgen Biosynthetic Process Glucocorticoid Metabolic Process Response To Insecticide Leydig Cell Differentiation Cellular Response To Antibiotic Small Molecule Metabolic Process Progesterone Metabolic Process Ovulation Glutathione Derivative Biosynthetic Process Cellular Response To Toxic Substance Cellular Response To Gonadotropin Stimulus Regulation Of Hormone Biosynthetic Process Mitotic Metaphase Plate Congression Mitotic Chromosome Condensation Positive Regulation Of Steroid Metabolic Process Sister Chromatid Cohesion C21-steroid Hormone Metabolic Process Metaphase Plate Congression Regulation Of Hormone Metabolic Process Cellular Response To Stimulus Androgen Metabolic Process Adrenal Gland Development Response To Gonadotropin Establishment Of Chromosome Localization Chromosome Condensation Hormone Biosynthetic Process Response To Antibiotic Positive Regulation Of Lipid Biosynthetic Process Glutathione Metabolic Process Regulation Of Steroid Biosynthetic Process Hippocampus Development Mitotic Sister Chromatid Segregation	Positive Regulation Of Ras Protein Signal Transduction Response To Light Stimulus Positive Regulation Of Small GTPase Mediated Signal Transduction Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Radiation Regulation Of MAPK Cascade Positive Regulation Of Rac Protein Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of MDA-5 Signaling Pathway Response To Stress Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Smooth Muscle Cell Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Modification Process Positive Regulation Of RIG-I Signaling Pathway
Tagcloud ?			aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 flnc gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?			aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 flnc gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?