RPAIN and ADH6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPAIN	ADH6
Description		RPA interacting protein	alcohol dehydrogenase 6 (class V)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm PML Body	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Protein Import Into Nucleus Response To UV	Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways			Ethanol oxidation
Drugs
Diseases
GWAS		Body mass index ( 29273807) Menopause (age at onset) ( 26414677) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Alcohol dependence ( 23456092) Alcohol use disorder (consumption score) ( 30336701 30940813) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Aspartate aminotransferase levels ( 33547301) Esophageal cancer ( 19698717) QRS duration ( 23534349) Regular attendance at a pub or social club ( 29970889) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		7 interacting genes: ADH6 CDCA5 CLNK CYP17A1 GSTA1 RAD51B TNS4	8 interacting genes: ANKRD17 ARRB1 KRAS RASSF5 RPAIN RPS29 RSL1D1 TNIP1
Entrez ID		84268	130
HPRD ID		14615	00067
Ensembl ID		ENSG00000129197	ENSG00000172955
Uniprot IDs		B3KTT3 Q86UA6	P28332 Q8IUN7
PDB IDs
Enriched GO Terms of Interacting Partners?		Olefinic Compound Metabolic Process Steroid 17-alpha-monooxygenase Activity Hormone Metabolic Process Oxidoreductase Activity Cortisol Biosynthetic Process Glucocorticoid Biosynthetic Process Cortisol Metabolic Process Glutathione Derivative Biosynthetic Process Steroid Delta-isomerase Activity Blastocyst Growth Rad51B-Rad51C-Rad51D-XRCC2 Complex Mast Cell Granule	Regulation Of Post-translational Protein Modification Regulation Of Cellular Senescence Regulation Of Canonical NF-kappaB Signal Transduction Leukocyte Cell-cell Adhesion Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Angiotensin Receptor Binding Regulation Of Intracellular Signal Transduction Response To Isolation Stress GMP Binding Forebrain Astrocyte Development Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of MDA-5 Signaling Pathway Cellular Detoxification Of Cadmium Ion Monoatomic Cation:bicarbonate Symporter Activity Cartilage Homeostasis
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