ADH6

Description		alcohol dehydrogenase 6 (class V)
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		Ethanol oxidation
Drugs
Diseases
GWAS		Alcohol dependence ( 23456092) Alcohol use disorder (consumption score) ( 30336701 30940813) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Aspartate aminotransferase levels ( 33547301) Esophageal cancer ( 19698717) QRS duration ( 23534349) Regular attendance at a pub or social club ( 29970889) Serum alkaline phosphatase levels ( 33547301)
Novel Interacting Genes		1 novel interacting genes: SLC39A8
Interacting Genes		8 interacting genes: ANKRD17 ARRB1 KRAS RASSF5 RPAIN RPS29 RSL1D1 TNIP1
Entrez ID		130
HPRD ID		00067
Ensembl ID		ENSG00000172955
Uniprot IDs		P28332 Q8IUN7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Post-translational Protein Modification Regulation Of Cellular Senescence Regulation Of Canonical NF-kappaB Signal Transduction Leukocyte Cell-cell Adhesion Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Angiotensin Receptor Binding Regulation Of Intracellular Signal Transduction Response To Isolation Stress GMP Binding Forebrain Astrocyte Development Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of MDA-5 Signaling Pathway Cellular Detoxification Of Cadmium Ion Monoatomic Cation:bicarbonate Symporter Activity Cartilage Homeostasis
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