ADH6 and ANKRD17

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADH6	ANKRD17
Gene Name		alcohol dehydrogenase 6 (class V)	ankyrin repeat domain 17
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Chromatin Nucleus Cytoplasm Membrane
	Molecular Function	Alcohol Dehydrogenase (NAD) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Zinc Ion Binding Ethanol Binding	Chromatin Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Ethanol Oxidation Xenobiotic Metabolic Process Small Molecule Metabolic Process Response To Ethanol	Blood Vessel Maturation Regulation Of DNA Replication Viral Process Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Ethanol oxidation Metabolic disorders of biological oxidation enzymes Defective CYP1B1 causes Glaucoma Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations
Drugs
Diseases
GWAS		Alcohol dependence ( 23456092) Esophageal cancer ( 19698717) QRS duration ( 23534349)	Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: ANKRD17 ARRB1 KRAS RASSF5 RPAIN RPS29 RSL1D1 TNIP1	5 interactors: ADH6 APC ITSN2 KIAA0368 MDM2
Entrez ID		130	26057
HPRD ID		00067	10648
Ensembl ID		ENSG00000172955	ENSG00000132466
Uniprot IDs		E9PBI1 P28332 Q8IUN7	E7EUV3 O75179
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ras Protein Signal Transduction Response To Light Stimulus Positive Regulation Of Small GTPase Mediated Signal Transduction Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Radiation Regulation Of MAPK Cascade Positive Regulation Of Rac Protein Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of MDA-5 Signaling Pathway Response To Stress Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Smooth Muscle Cell Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Modification Process Positive Regulation Of RIG-I Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cellular Macromolecule Catabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Odontogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Response To Vitamin B1 Response To Ether Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Response To UV-C Negative Regulation Of Protein Processing Proteolysis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Regulation Of Protein Catabolic Process Positive Regulation Of Pseudopodium Assembly Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Export From Nucleus Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Negative Regulation Of Intracellular Signal Transduction Ethanol Oxidation Negative Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Catabolic Process Response To Magnesium Ion Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Cell Cycle Process Cellular Response To Antibiotic Negative Regulation Of Cell Cycle Arrest Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 flnc gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic	add african alleles americans antihypertensive caucasian caucasians connections cox18 displaying diuretics elevations fto grin3a hctz heterozygotes hydrochlorothiazide hyperuricaemia luc7l2 padi4 pard3b pear pharmacogenomic replicated rs4784333 suggestive thiazide ua uric
Tagcloud (Difference) ?		aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 flnc gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic	add african alleles americans antihypertensive caucasian caucasians connections cox18 displaying diuretics elevations fto grin3a hctz heterozygotes hydrochlorothiazide hyperuricaemia luc7l2 padi4 pard3b pear pharmacogenomic replicated rs4784333 suggestive thiazide ua uric
Tagcloud (Intersection) ?