ADH6 and ANKRD17

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ADH6	ANKRD17
Description		alcohol dehydrogenase 6 (class V)	ankyrin repeat domain 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Membrane
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding	Nucleic Acid Binding Chromatin Binding RNA Binding Protein Binding
	Biological Process	Retinol Metabolic Process Retinoic Acid Metabolic Process	Immune System Process Regulation Of DNA Replication Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		Ethanol oxidation
Drugs
Diseases
GWAS		Alcohol dependence ( 23456092) Alcohol use disorder (consumption score) ( 30336701 30940813) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Aspartate aminotransferase levels ( 33547301) Esophageal cancer ( 19698717) QRS duration ( 23534349) Regular attendance at a pub or social club ( 29970889) Serum alkaline phosphatase levels ( 33547301)	Apolipoprotein B levels ( 32203549) Cholesterol ester levels in large LDL ( 29084231) Cholesterol ester levels in medium LDL ( 29084231) Esterified cholesterol levels ( 29084231) Free cholesterol levels in large LDL ( 29084231) Hematocrit ( 32888494) Large LDL particle concentration ( 29084231) Medium LDL particle concentration ( 29084231) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Smooth-surface caries ( 24556642) Total cholesterol levels in large LDL ( 29084231) Total cholesterol levels in medium LDL ( 29084231) Total cholesterol levels in small LDL ( 29084231)
Interacting Genes		8 interacting genes: ANKRD17 ARRB1 KRAS RASSF5 RPAIN RPS29 RSL1D1 TNIP1	6 interacting genes: ADH6 APC ECPAS ITSN2 MDM2 RNF10
Entrez ID		130	26057
HPRD ID		00067	10648
Ensembl ID		ENSG00000172955	ENSG00000132466
Uniprot IDs		P28332 Q8IUN7	O75179
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Post-translational Protein Modification Regulation Of Cellular Senescence Regulation Of Canonical NF-kappaB Signal Transduction Leukocyte Cell-cell Adhesion Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Angiotensin Receptor Binding Regulation Of Intracellular Signal Transduction Response To Isolation Stress GMP Binding Forebrain Astrocyte Development Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of MDA-5 Signaling Pathway Cellular Detoxification Of Cadmium Ion Monoatomic Cation:bicarbonate Symporter Activity Cartilage Homeostasis	Protein Catabolic Process Heart Valve Development Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Endocardial Cushion Morphogenesis Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Proteolysis Response To Formaldehyde Cellular Response To Vitamin B1 Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Clathrin-dependent Synaptic Vesicle Endocytosis Centrosome Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Regulation Of G1/S Transition Of Mitotic Cell Cycle NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To UV-C Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Catabolic Process Receptor Serine/threonine Kinase Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome Alcohol Dehydrogenase (NAD+) Activity Leading Edge Membrane Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Atrial Septum Development Fibroblast Activation Peroxisome Proliferator Activated Receptor Binding Cellular Response To Antibiotic 5S RRNA Binding Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation
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