DCUN1D5 and PLEKHG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DCUN1D5	PLEKHG4
Description		defective in cullin neddylation 1 domain containing 5	pleckstrin homology and RhoGEF domain containing G4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Spindle Cytoskeleton	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Regulation Of Cell Growth DNA Damage Response Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Neddylation	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Interleukin-10 levels ( 22205395) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)	A body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		11 interacting genes: CAND1 CHUK CUL2 CUL3 HUS1 LNX1 PICK1 PLEKHG4 RCHY1 UBE2F UBE2M	65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13B FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SAXO4 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		84259	25894
HPRD ID		14520	10890
Ensembl ID		ENSG00000137692	ENSG00000196155
Uniprot IDs		B4DP84 Q9BTE7	A0A024R6X4 Q58EX7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Cullin-RING Ubiquitin Ligase Complex Post-translational Protein Modification Ubiquitin-protein Transferase Activity NEDD8 Conjugating Enzyme Activity Protein Modification Process NEDD8 Transferase Activity Ubiquitin Ligase Complex Scaffold Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Cytosol Protein Metabolic Process Protein Neddylation Macromolecule Catabolic Process Macromolecule Metabolic Process Postsynapse Proteolysis Response To Acetate Protein Autoubiquitination Response To Cholecystokinin Meiotic DNA Integrity Checkpoint Signaling Trophectodermal Cellular Morphogenesis Cell Cycle G1/S Phase Transition Liver Morphogenesis G1/S Transition Of Mitotic Cell Cycle Ubiquitin Protein Ligase Activity SCF Complex Assembly Positive Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process IkappaB Kinase Activity Regulation Protein Catabolic Process At Postsynapse Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Response To Amino Acid POZ Domain Binding Membrane Curvature Sensor Activity NEDD8 Ligase Activity Regulation Of Type I Interferon Production Transferase Activity Checkpoint Clamp Complex Positive Regulation Of Post-translational Protein Modification Polar Microtubule Proteasomal Protein Catabolic Process Error-free Translesion Synthesis Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Mitotic Cell Cycle Phase Transition Nucleoplasm	Protein Binding Regulation Of Podosome Assembly Positive Regulation Of Ureteric Bud Formation
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