SPATC1L and TRMO

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPATC1L	TRMO
Description		spermatogenesis and centriole associated 1 like	tRNA methyltransferase O
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Sperm Head-tail Coupling Apparatus
	Molecular Function	Protein Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding	Protein Binding Methyltransferase Activity Transferase Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity
	Biological Process	Spermatogenesis Actin Polymerization Or Depolymerization Positive Regulation Of CAMP/PKA Signal Transduction	TRNA Processing TRNA Methylation Methylation
Pathways
Drugs
Diseases
GWAS			Orofacial clefts ( 33137956)
Interacting Genes		51 interacting genes: ACOT7 ARL4A ARMC7 ATPAF2 CABP2 CLTC DISC1 EXOSC8 FOXN1 FSD2 GOLGA6A GTF3C6 HOOK2 IKZF1 KIFC3 KRT40 KRTAP5-9 LZTS2 MISP MTUS2 MYO15B NCK2 NUTF2 NXF1 PARN PHC2 PHF11 PIAS2 PICK1 PINK1 PLEC PNMA1 POLR1C PPP1CB PPP1CC QARS1 RAD51D RBMY1F RBMY1J REL SIAH1 SNRNP70 SYCE1 TCF4 TEKT4 TRIM27 TRMO TSR2 UBL5 ZBTB4 ZBTB8B	22 interacting genes: AURKA BCL10 BMPR1A BUB1 CCND1 DCC DLC1 EGFR ERBB2 MCC MLH1 NRAS PMS2 PTEN PTPRJ RAD54B RB1 SMAD2 SPATC1L STAC STK11 TGFBR2
Entrez ID		84221	51531
HPRD ID		10753	12945
Ensembl ID		ENSG00000160284	ENSG00000136932
Uniprot IDs		Q9H0A9	Q5T114 Q9BU70
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Identical Protein Binding Nucleus RNA Metabolic Process PTW/PP1 Phosphatase Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing	Regulation Of Epithelial Cell Proliferation Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Protein Kinase Activity Regulation Of Cell Population Proliferation Signal Transduction Regulation Of Growth Kinase Activity Heart Valve Morphogenesis Regulation Of Phosphorylation Regulation Of Cell Differentiation Heart Development Negative Regulation Of Developmental Process Negative Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cell Population Proliferation Regulation Of Signal Transduction Endocardial Cushion Morphogenesis Nucleotide Binding Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Development Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process MutLalpha Complex Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Phosphorylation Ruffle Membrane Negative Regulation Of Growth Apoptotic Process Regulation Of Cell Growth Tricuspid Valve Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Programmed Cell Death Cytosol Cell Death Aortic Valve Morphogenesis Regulation Of Cell Cycle Phase Transition Mismatch Repair Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Cycle Process
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