SPATC1L and PARN

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		SPATC1L	PARN
Gene Name		spermatogenesis and centriole associated 1-like	poly(A)-specific ribonuclease
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	Molecular_function	Nucleotide Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Biological_process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Female Gamete Generation RNA Modification Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ARL4A ARMC7 FSD2 IKZF1 LZTS2 PARN PHC2 PNMA1 PPP1CC SIAH1 TCF4 TRIM27	5 interactors: KHSRP MAPKAPK2 MPHOSPH6 MPP6 SPATC1L
Entrez ID		84221	5073
HPRD ID		10753	07250
Ensembl ID		ENSG00000160284	ENSG00000140694
Uniprot IDs		Q9H0A9	B3KN69 B4DSB0 O95453
PDB IDs			2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?		Single Organism Reproductive Process Gamete Generation Reproductive Process Cell Cycle Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Glycogen Metabolic Process Positive Regulation Of Neutrophil Differentiation Polysaccharide Metabolic Process Reproduction Negative Regulation Of Interleukin-2 Secretion Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Spermatogenesis Male Gamete Generation Fat Cell Differentiation Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Energy Reserve Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Maintenance Of DNA Repeat Elements Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Calcium Ion Import Embryonic Hindgut Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Embryonic Genitalia Morphogenesis Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Myoblast Fate Commitment Negative Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma Secretion Positive Regulation Of Granulocyte Differentiation Regulation Of Protein Localization Regulation Of Canonical Wnt Signaling Pathway Secretory Granule Localization Cellular Carbohydrate Metabolic Process Spindle Midzone Assembly Hindgut Morphogenesis Insulin Metabolic Process Nucleocytoplasmic Transport Microtubule Severing Hindgut Development Nuclear Transport Wnt Signaling Pathway	Maturation Of 5.8S RRNA RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Macropinocytosis Ribonucleoprotein Complex Biogenesis Regulation Of MiRNA Metabolic Process 3'-UTR-mediated MRNA Stabilization
Tagcloud ?			ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr
Tagcloud (Difference) ?			ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr
Tagcloud (Intersection) ?