CHD6 and ARAF

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		CHD6	ARAF
Gene Name		chromodomain helicase DNA binding protein 6	A-Raf proto-oncogene, serine/threonine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase II, Core Complex	Cellular_component
	Molecular Function	Transcription Cofactor Binding DNA Binding Chromatin Binding ATP Binding ATP-dependent Helicase Activity DNA-dependent ATPase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Chromatin Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress	Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process
Pathways
Drugs			Adenosine triphosphate
Diseases
GWAS		Hippocampal atrophy ( 22745009)
Protein-Protein Interactions		6 interactors: ARAF ATXN1L HIST3H3 NFE2L2 TOLLIP ZFYVE9	38 interactors: AGTRAP ASS1 BAD CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS MAP2K1 MAP2K2 MLH1 MYO18A NELFCD NUDT14 PBK PDGFRB PIK3R1 PKM PRPF6 RABGGTB RGS12 RRAS RRAS2 TEKT4P2 TESK1 TIMM44 TIRAP WNK1 YWHAG YWHAZ
Entrez ID		84181	369
HPRD ID		13049	02405
Ensembl ID		ENSG00000124177	ENSG00000078061
Uniprot IDs		Q8TD26	B4DV85 P10398 Q96II5
PDB IDs		2EPB	1WXM
Enriched GO Terms of Interacting Partners?			Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cellular Response To Peptide Hormone Stimulus Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Signal Transduction Cellular Response To Peptide Cellular Response To Organonitrogen Compound Immune Response Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Locomotion Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Component Movement Signaling Response To Hormone Regulation Of Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Cell Migration Phosphorylation Response To Stimulus Regulation Of MAPK Cascade Response To Oleic Acid Intrinsic Apoptotic Signaling Pathway Response To Peptide Hormone Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Response To Peptide Positive Regulation Of Cell Motility Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Movement Positive Regulation Of MAP Kinase Activity Cellular Response To Insulin Stimulus
Tagcloud ?		arid1a ash1l atlas broadly colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating	al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Difference) ?		arid1a ash1l atlas broadly colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating	al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Intersection) ?