ZRANB3 and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		ZRANB3	KPNA4
Description		zinc finger RANBP2-type containing 3	karyopherin subunit alpha 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Replication Fork	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Helicase Activity Catalytic Activity Helicase Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP-dependent DNA/DNA Annealing Activity Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	DNA Repair DNA Damage Response Response To UV Replication Fork Processing Replication Fork Reversal	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Hip circumference ( 25673412) Low density lipoprotein cholesterol levels ( 32154731) Mosquito bite size ( 28199695) Type 2 diabetes ( 31324766) Waist circumference adjusted for body mass index ( 28552196)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		2 interacting genes: KPNA4 UBC	49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3
Entrez ID		84083	3840
HPRD ID		15896	04275
Ensembl ID		ENSG00000121988	ENSG00000186432
Uniprot IDs		F5GYN7 Q5FWF4	O00629
PDB IDs		5MKW 5MLO 5MLW 5YD8	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hippo Signaling NLS-bearing Protein Import Into Nucleus Dopamine Secretion Catecholamine Secretion Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Dopamine Transport NLS-dependent Protein Nuclear Import Complex Protein Tag Activity Monoamine Transport Regulation Of Hippo Signaling Male Germ Cell Nucleus	Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process
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