KATNAL1 and VPS4B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KATNAL1	VPS4B
Description		katanin catalytic subunit A1 like 1	vacuolar protein sorting 4 homolog B
Image
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Mitochondrion Centrosome Spindle Cytosol Cytoskeleton Microtubule Katanin Complex Microtubule Cytoskeleton Mitotic Spindle	Spindle Pole Nucleus Nuclear Pore Cytoplasm Endosome Centrosome Cytosol Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Extracellular Exosome Flemming Body ATPase Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Spermatogenesis Cytoplasmic Microtubule Organization Microtubule Severing	Angiogenesis Plasma Membrane Repair Potassium Ion Transport Autophagy Nucleus Organization Endosome Organization Vacuole Organization Vacuolar Transport Lysosomal Transport Mitotic Metaphase Chromosome Alignment Central Nervous System Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Cholesterol Transport Nuclear Membrane Reassembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Protein Depolymerization Cell Division Canonical Wnt Signaling Pathway Establishment Of Blood-brain Barrier Late Endosomal Microautophagy Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation ESCRT III Complex Disassembly
Pathways			Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Blood osmolality (transformed sodium) ( 28360221) Fat distribution (HIV) ( 21897333) Femur bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 27182965) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928) Refractive error ( 32231278) Type 2 diabetes ( 31049640)	Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		18 interacting genes: AIRIM ASCC2 BYSL CEP57L1 CFTR COX17 CTNNA3 GCC1 GUCA1A IQUB KATNBL1 KLC4 MEOX2 PGAM2 PITPNC1 SIAH1 VPS4B ZNF69	10 interacting genes: CFTR CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 KATNAL1 OGT VPS4A ZFYVE19
Entrez ID		84056	9525
HPRD ID		13753	15653
Ensembl ID		ENSG00000102781	ENSG00000119541
Uniprot IDs		B3KUK7 Q9BW62	O75351
PDB IDs		6B5C	1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y 7L9X
Enriched GO Terms of Interacting Partners?			Midbody Abscission Mitotic Cytokinetic Process ESCRT III Complex Disassembly ESCRT Complex Disassembly Cytokinetic Process Viral Budding From Plasma Membrane Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Viral Budding Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Membrane Fission Multivesicular Body-lysosome Fusion Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Lysosomal Membrane Organization Metaphase Chromosome Alignment Membrane Assembly Midbody Kinetochore Microtubule Chromosome Localization Regulation Of Mitotic Spindle Assembly Endosome Organization Nuclear Pore Nucleus Organization Multivesicular Body Membrane Vesicle Fusion Organelle Membrane Fusion Regulation Of Spindle Assembly Plasma Membrane Organization Lysosomal Transport Autophagy Organelle Fusion Regulation Of Mitotic Spindle Organization Protein-containing Complex Disassembly Multivesicular Body Viral Process Regulation Of Centrosome Duplication Membrane Fusion
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