PIP4K2B and TRIM55

Number of citations of the paper that reports this interaction (PubMedID 31391242)
0

Data Source:
BioGRID (two hybrid)

		PIP4K2B	TRIM55
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 beta	tripartite motif containing 55
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Microtubule
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding GTP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Protein Homodimerization Activity Phosphatidylinositol Kinase Activity	Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	Leukocyte Migration Involved In Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction Innate Immune Response Diapedesis Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Macrophage Migration
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs		Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 20881960 28552196 31562340)	Coronary heart disease event reduction (statin therapy interaction) ( 22666496) Metabolite levels ( 23823483) Recurrent major depressive disorder ( 29317602)
Interacting Genes		17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131	306 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AFM AGO2 AKR1C8 ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 ARL6IP4 ATG4D ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BCAT1 BCHE BRAP BRD4 BRWD1 BTBD9 BYSL C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CTSF CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DCTN3 DECR2 DEF8 DEK DES DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 EPS8L2 ESPL1 EZH2 FAM185A FAM90A1 FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNA FLNB FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 GRB14 HID1 HIRA HOXA1 HROB ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIF13A KIF1B KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAGE3 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MDM4 MIDN MIIP MKI67 MLH3 MLLT11 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC3 MYBPHL MYCT1 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NR2C2 NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF1 PCGF3 PCGF6 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PLEKHG4 PLXNA3 POLD1 POLR2E PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PYGM RABEPK RAD23A RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNF10 RNF114 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SET SHFL SLC6A13 SLFN12 SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 STAM SYMPK SYNCRIP TCAP TCP10L TEX19 THAP3 TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNI1 TNNI2 TNNI3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM27 TRIM35 TRIM41 TRIM54 TRIM63 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 UCHL3 UCHL5 UNKL USP13 USP28 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB14 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16
Entrez ID		8396	84675
HPRD ID		04463	05927
Ensembl ID		ENSG00000276293	ENSG00000147573
Uniprot IDs		P78356	Q9BYV6
PDB IDs		1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H 7EM1 7EM2 7EM3 7EM4 7EM5 7EM6 7EM7 7EM8 7N80 7N81
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of DNA Recombination Nucleoplasm Cajal Body Regulation Of Primary Metabolic Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Identical Protein Binding Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process DNA Metabolic Process DNA Damage Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Kynureninase Activity Telomere-telomerase Complex Assembly Regulation Of DNA Metabolic Process Response To Stress Positive Regulation Of Immunoglobulin Production Double-strand Break Repair Via Nonhomologous End Joining DNA Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Type I Hypersensitivity B Cell Affinity Maturation Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Response To Vitamin B6 Nuclear Proteasome Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Immunoglobulin Production Regulation Of Metabolic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Macromolecule Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase CK2 Complex	Protein Binding Post-translational Protein Modification Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Nucleus Protein Modification By Small Protein Conjugation Protein Deubiquitination Protein Modification By Small Protein Removal Z Disc Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Titin Binding Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Zinc Ion Binding Negative Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Transcription By RNA Polymerase II PRC1 Complex Sarcomere Organization Nucleoplasm Regulation Of RNA Metabolic Process Structural Constituent Of Muscle Contractile Muscle Fiber TORC1 Signaling TOR Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein K48-linked Deubiquitination PcG Protein Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of TORC1 Signaling K48-linked Deubiquitinase Activity Regulation Of Primary Metabolic Process Negative Regulation Of Protein Sumoylation Negative Regulation Of TORC1 Signaling Transcription Corepressor Activity Negative Regulation Of Translation Protein Metabolic Process Regulation Of Protein Sumoylation Negative Regulation Of Catabolic Process Sarcomere
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