PIP4K2B and KYNU

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIP4K2B	KYNU
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 beta	kynureninase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding GTP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Protein Homodimerization Activity Phosphatidylinositol Kinase Activity	Protein Binding Hydrolase Activity Pyridoxal Phosphate Binding Kynureninase Activity Protein Homodimerization Activity
	Biological Process	Lipid Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	L-tryptophan Catabolic Process Nucleoside Phosphate Metabolic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process L-tryptophan Catabolic Process To Kynurenine Quinolinate Biosynthetic Process Response To Type II Interferon 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Response To Vitamin B6 Anthranilate Metabolic Process Purine-containing Compound Metabolic Process L-kynurenine Catabolic Process
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus	Tryptophan catabolism
Drugs		Fostamatinib	Pyridoxal phosphate Alanine m-Hydroxyhippuric acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 20881960 28552196 31562340)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Asthma and eczema ( 34155719) Blood protein levels ( 30072576) Cataracts ( 34127677) Empathy quotient ( 29527006) Glomerular filtration rate in chronic kidney disease ( 26420894) Neurological blood protein biomarker levels ( 31320639) Platelet count ( 32888494) Response to SSRI (symptom remission) ( 29160301) Toenail selenium levels ( 25343990)
Interacting Genes		17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131	9 interacting genes: CDC42 CT55 CTBP2 FAM86C1P LMO4 MCCD1 MYOZ3 PIP4K2B RASSF3
Entrez ID		8396	8942
HPRD ID		04463	08940
Ensembl ID		ENSG00000276293	ENSG00000115919
Uniprot IDs		P78356	Q16719 Q53SX6
PDB IDs		1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H 7EM1 7EM2 7EM3 7EM4 7EM5 7EM6 7EM7 7EM8 7N80 7N81	2HZP 3E9K 7S3V
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of DNA Recombination Nucleoplasm Cajal Body Regulation Of Primary Metabolic Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Identical Protein Binding Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process DNA Metabolic Process DNA Damage Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Kynureninase Activity Telomere-telomerase Complex Assembly Regulation Of DNA Metabolic Process Response To Stress Positive Regulation Of Immunoglobulin Production Double-strand Break Repair Via Nonhomologous End Joining DNA Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Type I Hypersensitivity B Cell Affinity Maturation Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Response To Vitamin B6 Nuclear Proteasome Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Immunoglobulin Production Regulation Of Metabolic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Macromolecule Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase CK2 Complex
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