EFS and SORBS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EFS	SORBS2
Description		embryonal Fyn-associated substrate	sorbin and SH3 domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Apical Plasma Membrane Z Disc Lamellipodium Dendrite Cell Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle Identical Protein Binding
	Biological Process	Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Intracellular Signal Transduction	Cytoskeleton Organization Notch Signaling Pathway Cell Growth Involved In Cardiac Muscle Cell Development
Pathways
Drugs
Diseases
GWAS			Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Short-term memory (digit-span task) ( 30741946) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		36 interacting genes: ABI2 AGXT APP BCAR1 BDKRB2 BLK CCDC187 CRK FYN GLMN GPANK1 LHX8 LYST MYOZ3 NCK1 NCK2 NF1 NLGN3 NPAS2 NUP155 OSTF1 PIN1 PTK2 PTK2B PTPN12 SH2D3C SH3RF2 SORBS2 SORBS3 SRC TRAPPC6A TSSK1B UBASH3B UBC YES1 ZNF417	46 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SHANK3 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ
Entrez ID		10278	8470
HPRD ID		09932	12473
Ensembl ID		ENSG00000100842	ENSG00000154556
Uniprot IDs		O43281	A0A8Q3WKF2 A0A8Q3WKH1 A0A8Q3WKK4 B7Z3D7 B7Z997 O94875
PDB IDs			5VEI
Enriched GO Terms of Interacting Partners?		Signal Complex Assembly Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Anchoring Junction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeletal Anchor Activity Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Scaffold Protein Binding Signaling Receptor Activator Activity Regulation Of Cell Adhesion ERBB Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Motility Signaling Receptor Binding Positive Regulation Of Supramolecular Fiber Organization Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Intrinsic Apoptotic Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Response To Growth Factor Signal Transduction Positive Regulation Of Immune System Process Regulation Of Cell Motility Fc Receptor Signaling Pathway Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Locomotion Immune Response-activating Signaling Pathway Leukocyte Migration Regulation Of Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Postsynapse Organization Positive Regulation Of Signal Transduction Negative Regulation Of Immune System Process Phosphorylation	Focal Adhesion Cytosol Lamellipodium Regulation Of Cell Motility SH3 Domain Binding Regulation Of Locomotion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glutamatergic Synapse Regulation Of Cell Migration Cell-cell Junction Anchoring Junction Cadherin Binding Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Postsynaptic Density Actin Cytoskeleton Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Cell Migration Plasma Membrane Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Motility Actin Polymerization Or Depolymerization Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Signal Transduction Cell Motility Actin Filament Organization Negative Regulation Of Signal Transduction Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Negative Regulation Of Signaling Regulation Of Lymphocyte Migration Developmental Process Negative Regulation Of Cell Communication Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cytoskeleton Organization
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