EFS and SH2D3C

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EFS	SH2D3C
Gene Name		embryonal Fyn-associated substrate	SH2 domain containing 3C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Membrane
	Molecular Function	SH3 Domain Binding Protein Domain Specific Binding	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Cell Adhesion Intracellular Signal Transduction	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ABI2 APP BCAR1 BLK CRK FYN LYST NPAS2 NUP155 OSTF1 PTK2 PTK2B PTPN12 SH2D3C SORBS2 SORBS3 SRC TRAPPC6A TSSK1B UBC ZNF417	9 interactors: BCAR1 CARD11 EFS EPHB2 MAPK1 NEDD9 PTK2B SNCAIP SRC
Entrez ID		10278	10044
HPRD ID		09932	05284
Ensembl ID		ENSG00000100842	ENSG00000095370
Uniprot IDs		B4DJ56 O43281	B4DG32 E7EUN5 Q8N5H7
PDB IDs			3T6G
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Innate Immune Response Platelet Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Positive Regulation Of Immune System Process Blood Coagulation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Hemostasis Cell Activation Peptidyl-tyrosine Phosphorylation Immune Response-regulating Signaling Pathway Actin Filament Organization Cellular Response To Peptide Hormone Stimulus Cell Migration Cellular Response To Peptide Locomotion Regulation Of Body Fluid Levels Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Wound Healing Protein Autophosphorylation Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Defense Response Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Phosphorylation Neurotrophin Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Wounding Ephrin Receptor Signaling Pathway Response To Peptide Hormone Movement Of Cell Or Subcellular Component Cellular Response To Organonitrogen Compound Response To Peptide Fc Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Adhesion Response To Organonitrogen Compound Integrin-mediated Signaling Pathway Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway	Vascular Endothelial Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Adhesion Actin Filament Bundle Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Stress Fiber Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport T Cell Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Signal Complex Assembly Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epithelial Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Body Fluid Levels Signal Transduction Regulation Of Cell Migration Locomotion Platelet Activation Chemotaxis Actin Cytoskeleton Organization Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Immune Response Actin Filament-based Process Bone Resorption Neurotrophin Signaling Pathway Signaling Regulation Of Locomotion Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Component Movement Cell Communication Cell Proliferation B Cell Receptor Signaling Pathway
Tagcloud ?		alg aplastic austria beginning bmt cessation cr csa cured cyclosporin evaluable germany immunosuppressive ist mentioned microliter nonresponders pmn probability pts relapsed relapses resp saa sibling suffered tapering transfusions vsaa	aging ahr aryl committed competitive creb1 division exhaustion gata gfi h2a hematological hes1 hsc hscs hydrocarbon hyperproliferation implicate ink4a ko myelogenous pdp1 premature renewal repopulation serial splenic splenomegaly srpk2
Tagcloud (Difference) ?		alg aplastic austria beginning bmt cessation cr csa cured cyclosporin evaluable germany immunosuppressive ist mentioned microliter nonresponders pmn probability pts relapsed relapses resp saa sibling suffered tapering transfusions vsaa	aging ahr aryl committed competitive creb1 division exhaustion gata gfi h2a hematological hes1 hsc hscs hydrocarbon hyperproliferation implicate ink4a ko myelogenous pdp1 premature renewal repopulation serial splenic splenomegaly srpk2
Tagcloud (Intersection) ?