EFS and SH3RF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EFS	SH3RF2
Description		embryonal Fyn-associated substrate	SH3 domain containing ring finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion	Nucleus Nucleoplasm
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Zinc Ion Binding Transferase Activity Phosphatase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Intracellular Signal Transduction	Protein Ubiquitination Positive Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS			Bacteremia ( 27236921) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261)
Interacting Genes		36 interacting genes: ABI2 AGXT APP BCAR1 BDKRB2 BLK CCDC187 CRK FYN GLMN GPANK1 LHX8 LYST MYOZ3 NCK1 NCK2 NF1 NLGN3 NPAS2 NUP155 OSTF1 PIN1 PTK2 PTK2B PTPN12 SH2D3C SH3RF2 SORBS2 SORBS3 SRC TRAPPC6A TSSK1B UBASH3B UBC YES1 ZNF417	23 interacting genes: AKAP8L AMOTL2 APP ATXN7L2 BAG4 BANP CBY2 CCDC102B CYSRT1 EFS FASLG GOLGA2 HOMEZ LMNA LZTS2 MTUS2 NEK6 PAK4 PPP1CA PPP1CC RBPMS UBE2N VPS37C
Entrez ID		10278	153769
HPRD ID		09932	10229
Ensembl ID		ENSG00000100842	ENSG00000156463
Uniprot IDs		O43281	Q08AM8 Q8TEC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Signal Complex Assembly Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Anchoring Junction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeletal Anchor Activity Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Scaffold Protein Binding Signaling Receptor Activator Activity Regulation Of Cell Adhesion ERBB Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Motility Signaling Receptor Binding Positive Regulation Of Supramolecular Fiber Organization Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Intrinsic Apoptotic Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Response To Growth Factor Signal Transduction Positive Regulation Of Immune System Process Regulation Of Cell Motility Fc Receptor Signaling Pathway Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Locomotion Immune Response-activating Signaling Pathway Leukocyte Migration Regulation Of Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Postsynapse Organization Positive Regulation Of Signal Transduction Negative Regulation Of Immune System Process Phosphorylation	Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway PTW/PP1 Phosphatase Complex Response To Lead Ion Transition Metal Ion Binding Cell Division Nuclear Speck Cadherin Binding Involved In Cell-cell Adhesion Lamin Binding Membrane Disassembly Nuclear Membrane Disassembly Protein Serine/threonine Kinase Binding Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock
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