EIF2A and RNF4

Number of citations of the paper that reports this interaction (PubMedID 32360601)
37

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		EIF2A	RNF4
Description		eukaryotic translation initiation factor 2A	ring finger protein 4
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Eukaryotic Translation Initiation Factor 2 Complex Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End
	Molecular Function	TRNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding Cadherin Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Translation Translational Initiation Regulation Of Translation Positive Regulation Of Signal Transduction SREBP Signaling Pathway Ribosome Assembly Response To Amino Acid Starvation	DNA Damage Response Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly Negative Regulation Of Protein Localization To Chromatin
Pathways			Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)
Interacting Genes		7 interacting genes: APP BZW2 CEBPA EIF2AK2 MARK2 MLH1 RNF4	141 interacting genes: AIM2 AKAP17A AR ARID3C ARK2N ATF2 ATXN1 BCL2L1 BIRC6 BLM BTBD1 BTBD3 C14orf119 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH EIF2A ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK ID1 IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PARP1 PATZ1 PCBP3 PGR PHC1 PRMT5 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8 RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TOP2B TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UCHL1 UCHL5 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2
Entrez ID		83939	6047
HPRD ID		11739	04167
Ensembl ID		ENSG00000144895	ENSG00000063978
Uniprot IDs		F8WAE5 Q9BY44	P78317
PDB IDs		8DYS	2EA6 2XEU 4PPE
Enriched GO Terms of Interacting Partners?		Regulation Of Hematopoietic Stem Cell Proliferation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Translation Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Intermediate-density Lipoprotein Particle Positive Regulation Of Chemokine Production Positive Regulation Of Inflammatory Response Regulation Of Cell Activation Regulation Of Developmental Process Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Gene Expression NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Response To Peptide Response To Cytokine Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization	Identical Protein Binding Ubiquitin Conjugating Enzyme Activity Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Ubiquitin-protein Transferase Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II Keratinization Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Monoubiquitination Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein-containing Complex DNA Damage Response Positive Regulation Of Metabolic Process Signaling Adaptor Activity Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Nucleic Acid Metabolic Process Thioesterase Binding
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