EIF2A and BZW2

Number of citations of the paper that reports this interaction (PubMedID 21745818)
41

Data Source:
BioGRID (pull down)

		EIF2A	BZW2
Description		eukaryotic translation initiation factor 2A	basic leucine zipper and W2 domains 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Eukaryotic Translation Initiation Factor 2 Complex Blood Microparticle	Cytoplasm Membrane
	Molecular Function	TRNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding Cadherin Binding	Protein Binding Cadherin Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Positive Regulation Of Signal Transduction SREBP Signaling Pathway Ribosome Assembly Response To Amino Acid Starvation	Regulation Of Translation Regulation Of Translational Initiation
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Alzheimer's disease (cognitive decline) ( 23535033) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		7 interacting genes: APP BZW2 CEBPA EIF2AK2 MARK2 MLH1 RNF4	8 interacting genes: CDC42 CEBPA EIF2A EIF2B1 EIF3A GSK3B LINC01554 OGT
Entrez ID		83939	28969
HPRD ID		11739	16571
Ensembl ID		ENSG00000144895	ENSG00000136261
Uniprot IDs		F8WAE5 Q9BY44	B5MCE7 Q9Y6E2
PDB IDs		8DYS
Enriched GO Terms of Interacting Partners?		Regulation Of Hematopoietic Stem Cell Proliferation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Translation Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Intermediate-density Lipoprotein Particle Positive Regulation Of Chemokine Production Positive Regulation Of Inflammatory Response Regulation Of Cell Activation Regulation Of Developmental Process Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Gene Expression NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Response To Peptide Response To Cytokine Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization	Translational Initiation Cytoplasmic Translational Initiation Translation Initiation Factor Activity Translation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process ER-nucleus Signaling Pathway Macrophage Differentiation Neuron Projection Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Membraneless Organelle Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glyceryl-ether Monooxygenase Activity Protein-containing Complex GBD Domain Binding Storage Vacuole Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Establishment Of Cell Polarity Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Response To Cytokine Stimulus Regulation Of Protein-containing Complex Assembly CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity Translation Reinitiation Multi-eIF Complex Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Apolipoprotein A-I Receptor Binding
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