CYP21A2 and POTEB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYP21A2	POTEB3
Description		cytochrome P450 family 21 subfamily A member 2	POTE ankyrin domain family member B3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monooxygenase Activity Steroid 21-monooxygenase Activity Steroid Binding Iron Ion Binding Lipid Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding 17-hydroxyprogesterone 21-hydroxylase Activity Progesterone 21-hydroxylase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Sterol Metabolic Process Cortisol Biosynthetic Process
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP21A2 causes AH3
Drugs		Ketoconazole
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Congenital adrenal hyperplasia (CAH)
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clostridioides difficle infection ( 33841421) Diastolic blood pressure ( 25249183) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 25249183) Inflammatory bowel disease ( 28067908) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043) Prostate cancer ( 23535732) Systolic blood pressure ( 25249183) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: CRCT1 CREB5 CYSRT1 HOXA1 KRTAP1-3 KRTAP4-2 KRTAP9-2 LCE1D LCE1F LCE2C LCE3B LCE3C LCE3D LCE5A NBPF19 NOTCH2NLA NR4A3 NUFIP2 PICK1 POTEB3 POU4F2	8 interacting genes: CYP21A2 DRC4 KRTAP4-11 KRTAP4-5 KRTAP5-9 KRTAP9-2 MACO1 PHF19
Entrez ID		1589	102724631
HPRD ID		01942
Ensembl ID		ENSG00000231852	ENSG00000278522
Uniprot IDs		P08686 Q08AG9	A0A0C4DH93 A0A0G2JQB7 A0JP26 Q495V6
PDB IDs		4Y8W 5VBU
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development Identical Protein Binding CAMP Response Element Binding Keratin Filament Neuromuscular Process	Intermediate Filament Keratin Filament Hair Cycle 17-hydroxyprogesterone 21-hydroxylase Activity Progesterone 21-hydroxylase Activity Steroid 21-monooxygenase Activity Cortisol Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Cortisol Metabolic Process Positive Regulation Of Protein Localization To Cilium Histone H3K36me3 Reader Activity Neuronal Signal Transduction Rough Endoplasmic Reticulum Membrane Regulation Of Protein Localization To Cilium Brain Development
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