CYP21A2 and CRCT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYP21A2	CRCT1
Description		cytochrome P450 family 21 subfamily A member 2	cysteine rich C-terminal 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monooxygenase Activity Steroid 21-monooxygenase Activity Steroid Binding Iron Ion Binding Lipid Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding 17-hydroxyprogesterone 21-hydroxylase Activity Progesterone 21-hydroxylase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Sterol Metabolic Process Cortisol Biosynthetic Process
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP21A2 causes AH3
Drugs		Ketoconazole
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Congenital adrenal hyperplasia (CAH)
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clostridioides difficle infection ( 33841421) Diastolic blood pressure ( 25249183) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 25249183) Inflammatory bowel disease ( 28067908) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043) Prostate cancer ( 23535732) Systolic blood pressure ( 25249183) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI ( 34021172)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 21804549 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Obesity-related traits ( 23251661) Plantar warts ( 28928442)
Interacting Genes		21 interacting genes: CRCT1 CREB5 CYSRT1 HOXA1 KRTAP1-3 KRTAP4-2 KRTAP9-2 LCE1D LCE1F LCE2C LCE3B LCE3C LCE3D LCE5A NBPF19 NOTCH2NLA NR4A3 NUFIP2 PICK1 POTEB3 POU4F2	62 interacting genes: AGTRAP ALPP APLP1 CEP126 CHD3 CYP21A2 CYSRT1 EEF1A1 GRN IGSF21 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE3A LCE4A LRIF1 MACO1 MEOX2 NOTCH2NLA NUP62 OIT3 PLSCR4 PTN RGS17 RGS20 SDCBP2 SLC39A7 TGM1 TLE1 TRIM55 TRIM63 VIM VWC2L
Entrez ID		1589	54544
HPRD ID		01942	16635
Ensembl ID		ENSG00000231852	ENSG00000169509
Uniprot IDs		P08686 Q08AG9	Q9UGL9
PDB IDs		4Y8W 5VBU
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development Identical Protein Binding CAMP Response Element Binding Keratin Filament Neuromuscular Process	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Identical Protein Binding Protein Binding Positive Regulation Of Axon Regeneration
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