KRTAP3-2 and GAD1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		KRTAP3-2	GAD1
Description		keratin associated protein 3-2	glutamate decarboxylase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Cytoplasm Plasma Membrane Cell Cortex Vesicle Membrane Axon Axon Terminus Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse GABA-ergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process		L-glutamate Catabolic Process Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process Social Behavior Locomotory Exploration Behavior
Pathways		Keratinization	GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Pyridoxal phosphate Glutamic acid
Diseases			Cerebral palsy
GWAS			Menopause (age at onset) ( 26414677)
Interacting Genes		75 interacting genes: ADAM12 ADAMTSL3 AQP1 ARFGAP1 ATG9A CATSPER1 CCDC28A-AS1 CELF5 CERK CNNM3 COL8A1 CREB5 DHRS1 DUSP10 EFEMP2 FOXD2 FRS3 GAD1 GARIN6 GATA1 GUCD1 HOXA1 HOXB9 HYAL2 HYPK ITGB5 KIF25-AS1 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-12 KRTAP4-4 KRTAP9-2 KRTAP9-3 LASP1 LCE1A LCE1B LCE1F LCE2A LCE3A LCE3C LCE3D LCE3E LCE4A MAN2B2 MAPKBP1 NR1D2 NTM NUFIP2 OLIG3 OTX1 PCSK5 PLSCR3 POGZ POU4F2 PRR34 R3HDM2 SAXO4 SLC13A5 SMARCC1 SPATA31J1 SPRY1 TBC1D16 TRIM42 TRIP13 VASN YIPF3 ZIC1 ZIM2	18 interacting genes: AGTRAP BASP1 CALM1 CMTM5 GAD2 HAAO KRT31 KRT40 KRTAP3-2 MAL2 PPP2CA PPP2CB PRKACA PRKCE SNCA STK3 TRIM23 TRIP6
Entrez ID		83897	2571
HPRD ID		13938	12011
Ensembl ID		ENSG00000212900	ENSG00000128683
Uniprot IDs		Q9BYR7	A0A0S2Z3V5 Q8IVA8 Q99259
PDB IDs			2OKJ 3VP6
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization Keratin Filament Epidermis Development Tissue Development Protein Binding	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cytoskeleton Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of Sequestering Of Calcium Ion Tau Protein Binding Regulation Of Calcium Ion Transmembrane Transport Response To Metal Ion Dopamine Biosynthetic Process Regulation Of Microtubule Polymerization Enzyme Activator Activity Cellular Response To Epinephrine Stimulus Regulation Of Calcium Ion Transport Vascular Endothelial Cell Response To Fluid Shear Stress Response To Epinephrine Synaptic Transmission, Dopaminergic Regulation Of Monoatomic Cation Transmembrane Transport Cytosol Keratin Filament Regulation Of Microtubule Polymerization Or Depolymerization FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Protein Phosphatase Type 2A Complex Response To Lead Ion Catecholamine Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Ferrous Iron Binding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Chemical Synaptic Transmission Negative Regulation Of ATP Metabolic Process Calcium Channel Complex Phosphate-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Dopamine Metabolic Process Positive Regulation Of Synaptic Transmission Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Response To Fluid Shear Stress Cell Communication Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Spindle Pole L-amino Acid Metabolic Process Intermediate Filament Biogenic Amine Biosynthetic Process Amine Biosynthetic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Aromatic Amino Acid Metabolic Process Presynaptic Endocytosis
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