KRTAP3-2 and HYAL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRTAP3-2	HYAL2
Description		keratin associated protein 3-2	hyaluronidase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Golgi Membrane Cytoplasm Lysosome Endoplasmic Reticulum Cytosol Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Regulator Complex Side Of Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Virus Receptor Activity Transcription Coactivator Activity Hyalurononglucosaminidase Activity Protein Binding Hyaluronic Acid Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Enzyme Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Hyaluronoglucuronidase Activity Transforming Growth Factor Beta Binding
	Biological Process		Response To Reactive Oxygen Species Kidney Development Hematopoietic Progenitor Cell Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Response To Virus Negative Regulation Of Fibroblast Migration Hyaluronan Catabolic Process Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Urine Volume Monocyte Activation Positive Regulation Of Protein Import Into Nucleus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Symbiont Entry Into Host Cell Skeletal System Morphogenesis Positive Regulation Of Inflammatory Response Cartilage Development Defense Response To Virus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Renal Water Absorption Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Keratinization	Hyaluronan metabolism Hyaluronan degradation
Drugs
Diseases
GWAS			Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		75 interacting genes: ADAM12 ADAMTSL3 AQP1 ARFGAP1 ATG9A CATSPER1 CCDC28A-AS1 CELF5 CERK CNNM3 COL8A1 CREB5 DHRS1 DUSP10 EFEMP2 FOXD2 FRS3 GAD1 GARIN6 GATA1 GUCD1 HOXA1 HOXB9 HYAL2 HYPK ITGB5 KIF25-AS1 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-12 KRTAP4-4 KRTAP9-2 KRTAP9-3 LASP1 LCE1A LCE1B LCE1F LCE2A LCE3A LCE3C LCE3D LCE3E LCE4A MAN2B2 MAPKBP1 NR1D2 NTM NUFIP2 OLIG3 OTX1 PCSK5 PLSCR3 POGZ POU4F2 PRR34 R3HDM2 SAXO4 SLC13A5 SMARCC1 SPATA31J1 SPRY1 TBC1D16 TRIM42 TRIP13 VASN YIPF3 ZIC1 ZIM2	16 interacting genes: CYSRT1 FHL3 KRT31 KRT34 KRTAP1-1 KRTAP10-3 KRTAP3-2 KRTAP6-2 KRTAP6-3 MST1R PELI2 SMAD2 SMAD3 SMAD4 TRIM54 WWOX
Entrez ID		83897	8692
HPRD ID		13938	04649
Ensembl ID		ENSG00000212900	ENSG00000068001
Uniprot IDs		Q9BYR7	Q12891
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization Keratin Filament Epidermis Development Tissue Development Protein Binding	Intermediate Filament Keratin Filament SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding Response To Transforming Growth Factor Beta SMAD Protein Signal Transduction R-SMAD Binding Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Activin Receptor Signaling Pathway Endoderm Development Mesoderm Morphogenesis Gastrulation Pericardium Development Trophoblast Cell Migration Epithelial Cell Differentiation Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Transforming Growth Factor Beta Stimulus Tissue Morphogenesis Tissue Development Embryonic Foregut Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Nodal Signaling Pathway Co-SMAD Binding Secondary Palate Development Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Skeletal System Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Extrinsic Apoptotic Signaling Pathway Response To Growth Factor Regulation Of Extracellular Matrix Assembly Response To Glucose Morphogenesis Of An Epithelium Ameboidal-type Cell Migration Osteoblast Differentiation Adrenal Gland Development Response To Monosaccharide Positive Regulation Of Extracellular Matrix Organization Epidermis Development Embryonic Cranial Skeleton Morphogenesis Embryonic Axis Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytosol Response To Carbohydrate
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