SESN2 and ULK1

Number of citations of the paper that reports this interaction (PMID 25040165)
0

Data Source:
BioGRID (pull down)

		SESN2	ULK1
Gene Name		sestrin 2	unc-51 like autophagy activating kinase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Autophagic Vacuole Cytosol Cytoplasmic Vesicle Membrane Pre-autophagosomal Structure Membrane ATG1/UKL1 Signaling Complex Neuron Projection Neuronal Cell Body ULK1-ATG13-FIP200 Complex Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Pre-autophagosomal Structure Membrane Extrinsic Component Of Autophagic Vacuole Membrane
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Rab GTPase Binding Protein Kinase Binding Protein Complex Binding
	Biological Process	Fatty Acid Beta-oxidation Autophagy Response To Glucose Mitochondrial DNA Metabolic Process Response To Insulin Protein Kinase B Signaling Glucose Import Triglyceride Homeostasis Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Regulation Of Response To Reactive Oxygen Species Regulation Of CAMP-dependent Protein Kinase Activity	Autophagic Vacuole Assembly Protein Phosphorylation Ras Protein Signal Transduction Protein Localization Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Macroautophagy Cerebellar Granule Cell Differentiation Radial Glia Guided Migration Of Cerebellar Granule Cell Neuron Projection Regeneration Neuron Projection Development Receptor Internalization Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MDM2 PRDX1 ULK1	9 interactors: EXOC8 GABARAP GABARAPL2 MBP PPP1CA SDCBP SESN2 SQSTM1 SYNGAP1
Entrez ID		83667	8408
HPRD ID		06378	11933
Ensembl ID		ENSG00000130766	ENSG00000177169
Uniprot IDs		P58004	O75385
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Reactive Oxygen Species Cellular Response To UV-C Cellular Response To Vitamin B1 Cellular Response To Nutrient Levels Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Regulation Of Nucleocytoplasmic Transport Radial Glia Guided Migration Of Cerebellar Granule Cell Cellular Response To Extracellular Stimulus Cellular Response To Stress Regulation Of Intracellular Protein Transport Catabolic Process Traversing Start Control Point Of Mitotic Cell Cycle Response To Vitamin B1 Response To Ether Negative Regulation Of Collateral Sprouting Response To Oxidative Stress Response To Nutrient Levels Regulation Of Intracellular Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Extracellular Stimulus Response To Inorganic Substance Response To UV-C Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Export From Nucleus Cerebellar Granule Cell Differentiation Regulation Of Signal Transduction Positive Regulation Of Macroautophagy Regulation Of Protein Transport Cerebellar Granular Layer Morphogenesis Hydrogen Peroxide Catabolic Process Response To Magnesium Ion Regulation Of Signaling Cellular Response To Antibiotic Negative Regulation Of Cell Cycle Arrest Regulation Of Establishment Of Protein Localization Removal Of Superoxide Radicals Cellular Response To Superoxide Cerebellar Granular Layer Development Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Migration In Hindbrain Cellular Response To Toxic Substance Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle G1/S Phase Transition Protein Destabilization Natural Killer Cell Mediated Cytotoxicity Response To Stress Regulation Of Protein Localization Natural Killer Cell Mediated Immunity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Membrane Organization Autophagy Macroautophagy Response To External Stimulus Cellular Response To Starvation Protein Localization Nucleophagy Cellular Response To Nutrient Levels Response To Starvation Mitochondrion Degradation Cellular Response To Extracellular Stimulus Cellular Localization Cell Communication Organelle Disassembly Autophagic Vacuole Assembly Negative Regulation Of Axonogenesis Catabolic Process Cellular Component Assembly Mitochondrion Organization Exocyst Assembly Establishment Of Localization In Cell Response To Nutrient Levels Response To Extracellular Stimulus Negative Regulation Of Cell Morphogenesis Involved In Differentiation Vacuole Organization Regulation Of Glucose Metabolic Process Negative Regulation Of Neuron Projection Development Regulation Of Phosphorylation Signaling Cellular Protein Localization Membrane Fusion Defense Response To Nematode Synaptic Transmission Protein Transport Negative Regulation Of Cell Projection Organization Response To Stimulus Cellular Lipid Catabolic Process Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Regulation Of Axonogenesis Intracellular Transport Exocyst Localization Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Neuron Differentiation Response To Nematode Cellular Response To Stimulus Ras Protein Signal Transduction
Tagcloud ?		activates anticancer atf4 attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive triple unveiled xenograft yw3	antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite
Tagcloud (Difference) ?		activates anticancer atf4 attenuated cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive triple unveiled xenograft yw3	antiretroviral antiviral ascribed assemble atg8 autophagic becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite
Tagcloud (Intersection) ?		autophagy