PARP9 and H2BC21

Number of citations of the paper that reports this interaction (PubMedID 28525742)
54

Data Source:
BioGRID (enzymatic study)

		PARP9	H2BC21
Description		poly(ADP-ribose) polymerase family member 9	H2B clustered histone 21
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Protein-containing Complex Site Of DNA Damage	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Enzyme Inhibitor Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding NAD+ Binding ADP-D-ribose Binding STAT Family Protein Binding NAD+-protein-C-terminal Glycine ADP-ribosyltransferase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	DNA Damage Checkpoint Signaling Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process DNA Repair Double-strand Break Repair DNA Damage Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Viral Protein Processing NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Chromatin Binding Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of DNA-templated Transcription Defense Response To Virus Regulation Of Response To Type II Interferon Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Type II Interferon-mediated Signaling Pathway Protein Poly-ADP-ribosylation Positive Regulation Of Protein Localization To Nucleus	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		LDL cholesterol levels ( 32203549) Major depressive disorder ( 22472876) Parkinson's disease ( 32201043) Total cholesterol levels ( 30275531)
Interacting Genes		3 interacting genes: ANXA1 DTX3L H2BC21	73 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NEIL3 NPM1 PARP10 PARP9 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMU1 SPANXN2 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1
Entrez ID		83666	8349
HPRD ID		10686	03494
Ensembl ID		ENSG00000138496	ENSG00000184678
Uniprot IDs		Q59ER9 Q8IXQ6	Q16778
PDB IDs		5AIL	4NFT 6A7U 6KBB 6M4D 6M4G 6M4H 7BXT 7EA8 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8H1T 8SPS 8SPU 8SYP 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8YJF
Enriched GO Terms of Interacting Partners?		Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Immune Response Early Endosome Membrane Defense Response Response To External Biotic Stimulus Response To Other Organism Histone Ubiquitin Ligase Activity Histone H4K91 Ubiquitin Ligase Activity Myoblast Migration Involved In Skeletal Muscle Regeneration Positive Regulation Of Neutrophil Apoptotic Process Protein ADP-ribosyltransferase-substrate Adaptor Activity Regulation Of Neutrophil Apoptotic Process Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Early Endosome Neutrophil Clearance Phospholipase A2 Inhibitor Activity Positive Regulation Of Chromatin Binding Immune System Process Phospholipase Inhibitor Activity Regulation Of T-helper 1 Cell Differentiation Neutrophil Homeostasis Regulation Of Cell Cycle Phase Transition Positive Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Protein Localization To Early Endosome STAT Family Protein Binding Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Localization To Endosome Myoblast Migration Negative Regulation Of Type 2 Immune Response Peptide Cross-linking Cadherin Binding Involved In Cell-cell Adhesion Negative Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of T-helper Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Phagocytic Cup Positive Regulation Of Leukocyte Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Monocyte Chemotaxis Negative Regulation Of T-helper Cell Differentiation Apoptotic Cell Clearance Regulation Of Cell Cycle Process Arachidonate Secretion Negative Regulation Of Interleukin-8 Production Positive Regulation Of Vesicle Fusion	Chromatin Organization Chromatin Remodeling Histone Binding Nucleoplasm Nucleus Protein Modification Process Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Post-translational Protein Modification Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Macromolecule Metabolic Process Transferase Activity Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K18 Acetyltransferase Activity
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