PARP9 and DTX3L

Number of citations of the paper that reports this interaction (PubMedID 12670957)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PARP9	DTX3L
Description		poly(ADP-ribose) polymerase family member 9	deltex E3 ubiquitin ligase 3L
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Protein-containing Complex Site Of DNA Damage	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex
	Molecular Function	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Enzyme Inhibitor Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding NAD+ Binding ADP-D-ribose Binding STAT Family Protein Binding NAD+-protein-C-terminal Glycine ADP-ribosyltransferase Activity	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity Histone Ubiquitin Ligase Activity Histone H4K91 Ubiquitin Ligase Activity
	Biological Process	DNA Damage Checkpoint Signaling Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process DNA Repair Double-strand Break Repair DNA Damage Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Viral Protein Processing NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Chromatin Binding Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of DNA-templated Transcription Defense Response To Virus Regulation Of Response To Type II Interferon Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Type II Interferon-mediated Signaling Pathway Protein Poly-ADP-ribosylation Positive Regulation Of Protein Localization To Nucleus	DNA Damage Checkpoint Signaling Positive Regulation Of Defense Response To Virus By Host Immune System Process DNA Repair Double-strand Break Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Notch Signaling Pathway Endosome To Lysosome Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Binding Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		LDL cholesterol levels ( 32203549) Major depressive disorder ( 22472876) Parkinson's disease ( 32201043) Total cholesterol levels ( 30275531)	Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)
Interacting Genes		3 interacting genes: ANXA1 DTX3L H2BC21	22 interacting genes: ANTXR1 DTX1 H2AC4 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W
Entrez ID		83666	151636
HPRD ID		10686	16843
Ensembl ID		ENSG00000138496	ENSG00000163840
Uniprot IDs		Q59ER9 Q8IXQ6	Q8TDB6
PDB IDs		5AIL	3PG6 8R79
Enriched GO Terms of Interacting Partners?		Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Immune Response Early Endosome Membrane Defense Response Response To External Biotic Stimulus Response To Other Organism Histone Ubiquitin Ligase Activity Histone H4K91 Ubiquitin Ligase Activity Myoblast Migration Involved In Skeletal Muscle Regeneration Positive Regulation Of Neutrophil Apoptotic Process Protein ADP-ribosyltransferase-substrate Adaptor Activity Regulation Of Neutrophil Apoptotic Process Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Early Endosome Neutrophil Clearance Phospholipase A2 Inhibitor Activity Positive Regulation Of Chromatin Binding Immune System Process Phospholipase Inhibitor Activity Regulation Of T-helper 1 Cell Differentiation Neutrophil Homeostasis Regulation Of Cell Cycle Phase Transition Positive Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Protein Localization To Early Endosome STAT Family Protein Binding Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Localization To Endosome Myoblast Migration Negative Regulation Of Type 2 Immune Response Peptide Cross-linking Cadherin Binding Involved In Cell-cell Adhesion Negative Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of T-helper Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Phagocytic Cup Positive Regulation Of Leukocyte Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Monocyte Chemotaxis Negative Regulation Of T-helper Cell Differentiation Apoptotic Cell Clearance Regulation Of Cell Cycle Process Arachidonate Secretion Negative Regulation Of Interleukin-8 Production Positive Regulation Of Vesicle Fusion	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Metabolic Process ATP Binding Catabolic Process Ubiquitin Protein Ligase Activity Nucleotide Binding Macromolecule Metabolic Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Nucleus Proteasomal Protein Catabolic Process ISG15-protein Conjugation Protein Catabolic Process Protein Autoubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cytosol Endosome Membrane Protein K6-linked Ubiquitination Ubiquitin-like Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process SUMO Conjugating Enzyme Activity NAD+-protein-C-terminal Glycine ADP-ribosyltransferase Activity Nucleoplasm Regulation Of Signal Transduction Protein-containing Complex Global Genome Nucleotide-excision Repair ADP-D-ribose Binding
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