RASSF5 and LSM7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RASSF5	LSM7
Description		Ras association domain family member 5	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	RNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of Protein Ubiquitination Lymphocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Regulation Of Protein Localization To Nucleus	MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Late-onset Alzheimer's disease ( 27770636) Neurofibrillary tangles ( 25188341)	Parkinson's disease ( 28892059)
Interacting Genes		30 interacting genes: ADH6 AMOTL2 APPBP2 BTRC HRAS KRAS KRT40 KRTAP4-2 LSM7 MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 UBQLN2 VPS28	24 interacting genes: CEBPA DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26
Entrez ID		83593	51690
HPRD ID		06117	06287
Ensembl ID		ENSG00000266094	ENSG00000130332
Uniprot IDs		A8K5F3 Q8WWW0	Q9UK45
PDB IDs		4LGD 4OH8	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		GDP Binding Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Intracellular Signal Transduction G Protein Activity Ras Protein Signal Transduction GTPase Activity GTP Binding Signal Transduction Cytosol Rap Protein Signal Transduction Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Schwann Cell Migration Regulation Of Signal Transduction Regulation Of Protein Modification Process Regulation Of MAPK Cascade Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Branching Morphogenesis Of An Epithelial Tube Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of JNK Cascade Thioesterase Binding Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Vesicle Membrane Morphogenesis Of An Epithelium Hydrolase Activity Macromolecule Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Modification-dependent Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Protein Modification Process Positive Regulation Of ERAD Pathway Positive Regulation Of Protein Catabolic Process Bounding Membrane Of Organelle Regulation Of Protein Phosphorylation Regulation Of Glial Cell Migration Autophagosome Assembly	U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions Lsm1-7-Pat1 Complex MRNA Metabolic Process RNA Splicing MRNA Processing Spliceosomal Complex RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Precatalytic Spliceosome MRNA Catabolic Process Ribonucleoprotein Complex Nucleobase-containing Compound Metabolic Process RNA Catabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Catabolic Process Nucleic Acid Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex RNA Binding Catalytic Step 2 Spliceosome P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNP Nuclear MRNA Surveillance Methylosome U6 SnRNA Binding Protein-RNA Complex Assembly Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) U1 SnRNP Nucleoplasm U5 SnRNP SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Macromolecule Catabolic Process U2-type Prespliceosome Assembly U12-type Spliceosomal Complex
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