PHF8

Gene Name		PHD finger protein 8
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	Chromatin Binding Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Methylated Histone Binding Histone Demethylase Activity (H4-K20 Specific) Histone Demethylase Activity (H3-K36 Specific) Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromatin Organization Transcription, DNA-templated Brain Development Histone H3-K9 Demethylation Histone H4-K20 Demethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase I Promoter Oxidation-reduction Process Negative Regulation Of Chromatin Silencing At RDNA Histone H3-K36 Demethylation Histone H3-K27 Demethylation
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379)
Protein-protein Interactions		6 interactors: APP HIST1H3A HIST1H4A HIST3H3 POLR2A RARA
Entrez ID		23133
HPRD ID		06599
Ensembl ID		ENSG00000172943
Uniprot IDs		O95327 Q9UPP1
PDB IDs		2WWU 3K3N 3K3O 3KV4 4DO0
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Negative Regulation Of Cell Differentiation Chromatin Silencing Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Methylation Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Nitrogen Compound Metabolic Process Negative Regulation Of Myeloid Cell Differentiation DNA Modification Sertoli Cell Fate Commitment Regulation Of Cell Differentiation Gene Silencing Gene Expression Nucleosome Assembly Chromatin Assembly Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Nucleosome Organization Developmental Growth Involved In Morphogenesis Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Collateral Sprouting In Absence Of Injury Histone H4-K20 Demethylation Transcription Initiation From RNA Polymerase II Promoter Regulation Of Myeloid Cell Differentiation Negative Regulation Of Cellular Metabolic Process DNA Packaging Chondroblast Differentiation Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Chromosome Organization Axon Choice Point Recognition Regulation Of Binding Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		assaying astrocytes cd11b cns demethylases demethylation fcm fixative gfap h3k27 jhdm1d jmjd1c jmjd2d jmjd3 jmjd5 jumonji lowest messenger microglia multiparametric mzbf neun optimized profiled simultaneously sort sorted transcriptionally utx