PHF8

Description		PHD finger protein 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K9 Demethylase Activity Histone H4K20 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K27me2/H3K27me3 Demethylase Activity Histone H3K4me3 Reader Activity Histone H3K36me/H3K36me2 Demethylase Activity Histone H3K9me/H3K9me2 Demethylase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Brain Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RDNA Heterochromatin Formation
Pathways		HDMs demethylate histones
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder and schizophrenia ( 21057379)
Interacting Genes		7 interacting genes: APP H3-4 H3C1 H4C1 POLR2A RARA SUMO2
Entrez ID		23133
HPRD ID		06599
Ensembl ID		ENSG00000172943
Uniprot IDs		H0Y3N9 O95327 Q9UPP1
PDB IDs		2WWU 3K3N 3K3O 3KV4 4DO0 7CMZ
Enriched GO Terms of Interacting Partners?		Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization DNA Binding Negative Regulation Of MiRNA Transcription Protein-DNA Complex Assembly Chromatin Remodeling Chromosome Protein-containing Complex MRNA Transcription By RNA Polymerase II Chromatin Organization MRNA Transcription Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway Sertoli Cell Fate Commitment Regulation Of MiRNA Metabolic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of Myeloid Cell Differentiation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Type II Interferon Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Nucleoplasm RNA-directed RNA Polymerase Activity RNA-templated Transcription Telomere Organization Protein-containing Complex Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Trachea Cartilage Development
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