YY1 and FKBP3

Number of citations of the paper that reports this interaction (PubMedID 11532945)
48

Data Source:
HPRD (in vivo, in vitro)

		YY1	FKBP3
Description		YY1 transcription factor	FKBP prolyl isomerase 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Nuclear Matrix Ino80 Complex PcG Protein Complex	Nucleus
	Molecular Function	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Isomerase Activity Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Localization DNA Damage Response Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Cell Differentiation B Cell Differentiation Negative Regulation Of Interferon-beta Production Regulation Of Chromosome Organization Cellular Response To UV Response To Prostaglandin F Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Camera-type Eye Morphogenesis Chromosome Organization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of MiRNA Transcription Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)	Hypertensive renal disease ( 34067580)
Interacting Genes		98 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BRCA1 CDKN2A CEBPA CEP76 CREB1 CREBBP CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 FOXP1 FOXP2 FOXP4 GFER GMCL1 GRN GTF2I HDAC2 HDAC3 HMGB1 HNF1B HOXA11 IL10 ITCH KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 MDFI MED20 MTA2 MYC NEDD4L NFIC NFIX NFKB1 NOTCH1 NPM1 NR1H2 PIAS4 PLEKHF2 PPIA PSMD9 RAF1 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UBE2I UHRF2 USP21 USP7 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2	17 interacting genes: BARD1 CALM1 CDC42 CEBPA CSNK2A1 CSNK2A2 CSNK2B ERBB2 FBXO25 HDAC1 HDAC2 MTA2 NEDD4 NEDD4L SMURF1 SRPK1 YY1
Entrez ID		7528	2287
HPRD ID		02482	01743
Ensembl ID		ENSG00000100811	ENSG00000100442
Uniprot IDs		P25490	Q00688
PDB IDs		1UBD 1ZNM 4C5I	1PBK 2KFV 2MPH 5D75 5GPG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intermediate Filament Chromatin Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Keratin Filament Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Transcription Regulator Complex Chromatin Remodeling	Protein Kinase CK2 Complex PcG Protein Complex Nucleoplasm Regulation Of Protein Catabolic Process Chromatin Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process NuRD Complex DNA-binding Transcription Factor Binding Histone Deacetylase Activity Receptor Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Sin3-type Complex Positive Regulation Of Protein Catabolic Process Regulation Of Cell Growth Regulation Of Cell Fate Specification Symbiont-mediated Disruption Of Host Cell PML Body Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Growth Ubiquitin-protein Transferase Activity Protein-containing Complex Chromatin Binding Macromolecule Metabolic Process Wnt Signaling Pathway Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Primary Metabolic Process Neuromuscular Junction Development Histone Deacetylase Binding Nucleosomal DNA Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hair Follicle Placode Formation Histone Deacetylase Complex Positive Regulation Of Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Fate Commitment Receptor Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Metabolic Process Intracellular Signal Transduction Regulation Of Growth Protein Targeting To Vacuole Ubiquitin Protein Ligase Activity Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process
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