CAPNS2 and PHACTR3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CAPNS2	PHACTR3
Name		calpain small subunit 2	phosphatase and actin regulator 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Calpain Complex	Nucleus Nucleoplasm Nuclear Matrix
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding
	Biological Process	None	Actin Cytoskeleton Organization
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	None
GWAS		Thyroid hormone levels ( 23408906 )	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30891314 ) Schizophrenia ( 30285260 )
Interacting Genes		9 interacting genes: APP ARMC10 CAPN2 CMTM5 OXNAD1 PHACTR3 PPIC PRPF31 RIN1	10 interacting genes: CAPNS2 CYB5B EEF1G MAPK6 PLPP6 PPP1CA PPP1CB TAB1 UBIAD1 UBL5
Entrez ID		84290	116154
HPRD ID		16682	10571
Ensembl ID		ENSG00000256812	ENSG00000087495
Uniprot IDs		Q96L46	B7Z339 Q96KR7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Endocytosis Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phosphatidylcholine Biosynthetic Process Calpain Complex Protein Catabolic Process At Postsynapse Regulation Of Phosphatidylcholine Biosynthetic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress SnRNP Binding U4atac SnRNP Ribonucleoprotein Complex Localization SnoRNA Localization U4atac SnRNA Binding Regulation Of Growth Rate DNA Binding Domain Binding Positive Regulation Of Growth Rate Regulation Of Interleukin-6 Production Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Spliceosomal Tri-snRNP Complex Import Into Cell Axon Choice Point Recognition U4 SnRNA Binding	PTW/PP1 Phosphatase Complex Protein Serine/threonine Phosphatase Activity Dephosphorylation Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Glycogen Metabolic Process Myosin-light-chain-phosphatase Activity Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Septin Cytoskeleton Protein Modification Process Lung Development Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Nitric-oxide Synthase Complex Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Regulation Of Circadian Rhythm Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Myosin Phosphatase Activity Endoplasmic Reticulum Membrane Calpain Complex Protein Metabolic Process Phosphoprotein Phosphatase Activity Circadian Rhythm Nitrite Reductase (NO-forming) Activity Lipid Phosphatase Activity Glycogen Granule Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Menaquinone Metabolic Process Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Lysophosphatidic Acid Phosphatase Activity RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Chromosome, Telomeric Region Positive Regulation Of CGAS/STING Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Double-strand Break Repair Via Alternative Nonhomologous End Joining