GATD3 and SNRNP70

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		GATD3	SNRNP70
Description		glutamine amidotransferase class 1 domain containing 3	small nuclear ribonucleoprotein U1 subunit 70
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck Lysosomal Lumen U2-type Prespliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding U1 SnRNA Binding U1 SnRNP Binding
	Biological Process		MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chaperone-mediated Autophagy
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653) Venous thromboembolism ( 33592630)
Interacting Genes		8 interacting genes: APP COPS5 FRA10AC1 PAX6 PJA1 RANBP9 SNRNP70 TAF1	67 interacting genes: ADARB1 APP ARSF BACE2 CASP3 CBS CDC42 CDKL3 CEBPA CEP63 CFAP298 CHERP CRP CTDP1 DDX17 DYRK1A FTCD GATD3 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 HUNK IL32 IL7R ITSN1 LRP1 MYC NUDT21 OGT PDE9A PIGP PRKD2 PRMT5 PRPF40A PRPF6 PSMG1 RASGRF1 RBM11 RELA RIPPLY3 RNF11 RSPH1 RUNX1 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SPATC1L SRPK1 SRRM4 SRSF1 SRSF10 SRSF2 SUMO3 TIAM1 USP25 USP7 WBP4 ZRANB2
Entrez ID		8209	6625
HPRD ID		09044	01617
Ensembl ID		ENSG00000160221	ENSG00000104852
Uniprot IDs		A0A140VKB0 F2Z2Q0 P0DPI2	P08621 Q9UFS1
PDB IDs			2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9 7B0Y 7VPX 8R08
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Enzyme Binding Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Forebrain-midbrain Boundary Formation Pancreatic A Cell Development RNA Polymerase II Core Promoter Sequence-specific DNA Binding Habenula Development Pallium Development Neural Precursor Cell Proliferation Negative Regulation Of Protein Refolding Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Protein Autoubiquitination Positive Regulation Of Androgen Receptor Signaling Pathway GET Complex Proteasome Core Complex Assembly Macrophage Migration Inhibitory Factor Binding Regulation Of Spontaneous Synaptic Transmission Response To Purine-containing Compound Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of RNA Metabolic Process	SMAD Protein Complex MRNA Processing Heteromeric SMAD Protein Complex RNA Metabolic Process RNA Processing RNA Splicing Nucleoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process I-SMAD Binding Regulation Of MRNA Splicing, Via Spliceosome SMAD Protein Signal Transduction RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Growth Factor Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Positive Regulation Of Developmental Process Identical Protein Binding Embryonic Pattern Specification Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cardiac Conduction System Development Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Transcription Spliceosomal SnRNP Assembly Nuclear Speck Positive Regulation Of Cell Differentiation Spliceosomal Complex Assembly Protein-containing Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression DEAD/H-box RNA Helicase Binding RNA Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process
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