CHAF1B and RBBP4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical)
HPRD (in vivo)

		CHAF1B	RBBP4
Description		chromatin assembly factor 1 subunit B	RB binding protein 4, chromatin remodeling factor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex CAF-1 Complex	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol NuRD Complex NURF Complex Protein-containing Complex CAF-1 Complex ESC/E(Z) Complex Sin3-type Complex ATPase Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Unfolded Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding ATP-dependent Activity, Acting On DNA Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding
	Biological Process	DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly DNA Damage Response	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Brain Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation
Pathways			Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Creatinine levels ( 29403010) Height ( 31562340) Pulmonary function ( 23932459)
Interacting Genes		13 interacting genes: APP ASF1A ASF1B CDK1 CDK2 CHAF1A CUX1 H3-4 H3C6 PLEKHH1 RBBP4 SUMO2 ZNF879	59 interacting genes: AEBP2 ANXA7 ARMC12 BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP CYTOR DDB1 DHX30 ESR1 EXOSC8 FOXK2 H1-1 H2AC20 H3-4 H3C1 H3C14 H4C14 H4C16 HDAC1 HDAC2 HDAC3 HDAC4 HMOX2 ING1 KPNA5 LIN9 LMNA MBD2 MBD3 MTA1 MTA2 NR2E3 PRDM16 RB1 RBBP7 RBP1 RPN1 RPN2 RYBP SALL4 SAP30 SIN3A SMN1 SNCA SP1 SP3 SPEN STAT5B SUMO2 SUV39H1 TK1 TSSK3 USP7 XRCC6
Entrez ID		8208	5928
HPRD ID		03147	04232
Ensembl ID		ENSG00000159259	ENSG00000162521
Uniprot IDs		Q13112	Q09028
PDB IDs		7Y5K 7Y5L 7Y5O 7Y5U 7Y5V 7Y60 7Y61 8IQF 8IQG 8J6S 8J6T	2XU7 3GFC 4PBY 4PBZ 4PC0 4R7A 5FXY 5VTB 5WAI 5WAK 5XWR 5XXQ 5Y1U 6BW3 6BW4 6C23 6C24 6G16 6NQ3 6WKR 6ZRC 6ZRD 7AOA 7KSO 7KSR 7KTP 7M40 7N40 7R1D 7Y5K 7Y5L 7Y5O 7Y5U 7Y5V 8EQV 8FYH 8IQF 8IQG 8T9G 8TAS 8TB9 8TX8 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Nucleosome Organization Protein-DNA Complex Assembly Cyclin-dependent Protein Kinase Activity CAF-1 Complex DNA Replication Histone Kinase Activity Protein-containing Complex Assembly Chromosome, Telomeric Region Protein-containing Complex Organization Histone Chaperone Activity Protein-containing Complex DNA Repair Cellular Component Assembly Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin Binding Response To Copper Ion Extracellular Exosome Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity DNA Metabolic Process Pronuclear Fusion DNA Damage Response Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Histone Binding Chromatin Binding G2/M Transition Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Regulation Of Transcription By RNA Polymerase II Lipoprotein Particle Positive Regulation Of Protein Import 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Cell Cycle G2/M Phase Transition Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex	Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Nucleus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Heterochromatin Formation Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance DNA Binding Histone Deacetylase Complex NuRD Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Repressor Complex Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Rhythmic Process Chromatin Binding Positive Regulation Of Stem Cell Population Maintenance Regulation Of Macromolecule Metabolic Process Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Developmental Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Chromosome
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