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SPRY4 and TESK1
Number of citations of the paper that reports this interaction (PubMedID
12027893
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
SPRY4
TESK1
Description
sprouty RTK signaling antagonist 4
testis associated actin remodelling kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Ruffle Membrane
Cell Projection
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Lamellipodium
Cytoplasmic Vesicle
Cell Projection
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Kinase Inhibitor Activity
Protein Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Regulation Of Signal Transduction
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Cellular Response To Leukemia Inhibitory Factor
Spermatogenesis
Actin Cytoskeleton Organization
Regulation Of Protein Localization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Stress Fiber Assembly
Establishment Of Vesicle Localization
Nuclear-transcribed MRNA Catabolic Process, No-go Decay
Podocyte Cell Migration
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Cilium Assembly
Pathways
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Fostamatinib
Diseases
GWAS
Asthma (
29273806
31959851
)
Body mass index (
28552196
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Erosive tooth wear (severe vs none or mild) (
29898447
)
Gut microbiota (bacterial taxa) (
27723756
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
Physiological traits (
31902109
)
Systolic blood pressure (
30578418
)
Testicular germ cell cancer (
20543847
)
Testicular germ cell tumor (
19483681
23666239
23666240
28604728
28604732
)
Interacting Genes
17 interacting genes:
ADAM12
COL8A1
CREB5
EFEMP2
FHL2
HOXA1
KLHL38
KRTAP5-11
NUTF2
OTX1
POU4F2
RAF1
RIN3
TESK1
TNS2
VENTX
ZDHHC17
7 interacting genes:
ABCB4
ARAF
CFL1
PFKL
SPRY4
YWHAB
YY1
Entrez ID
81848
7016
HPRD ID
10466
03470
Ensembl ID
ENSG00000187678
ENSG00000107140
Uniprot IDs
A0A0C4DFS6
Q9C004
Q15569
Q8NFJ4
PDB IDs
3BUN
Enriched GO Terms of Interacting Partners
?
Response To Ether
Focal Adhesion
Cofilin-actin Rod
Cellular Response To Interleukin-1
Negative Regulation Of Unidimensional Cell Growth
Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape
Positive Regulation Of Barbed-end Actin Filament Capping
Positive Regulation Of Protein Localization To Cell Leading Edge
Protein Kinase Inhibitor Activity
Response To Interleukin-1
Regulation Of Embryonic Development
Negative Regulation Of Developmental Growth
Cellular Response To Cytokine Stimulus
Ruffle Membrane
Negative Regulation Of Postsynaptic Density Organization
Response To Fenofibrate
Immunoglobulin Heavy Chain V-D-J Recombination
Regulation Of Protein Localization To Cell Leading Edge
6-phosphofructokinase Activity
Negative Regulation Of Protein Transport
6-phosphofructokinase Complex
Cellular Response To Bile Acid
Ceramide Floppase Activity
Ceramide Translocation
Response To Prostaglandin F
Interleukin-17 Receptor Activity
Nuclear Matrix
Response To Peptide
Response To Cytokine
Neural Fold Formation
Actin Filament Fragmentation
Fructose-6-phosphate Binding
Negative Regulation Of Establishment Of Protein Localization
Negative Regulation Of Cell Growth
Negative Regulation Of Dendritic Spine Maintenance
Regulation Of Barbed-end Actin Filament Capping
Negative Regulation Of Lamellipodium Assembly
Intercellular Canaliculus
Positive Regulation Of Phospholipid Translocation
Bile Acid Secretion
Sphingolipid Translocation
Response To Bile Acid
Phosphatidylcholine Floppase Activity
Phosphoserine Residue Binding
T-helper 17 Type Immune Response
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Interleukin-17A-mediated Signaling Pathway
Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Fructose Binding
Monosaccharide Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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