SPRY4 and POU4F2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPRY4	POU4F2
Description		sprouty RTK signaling antagonist 4	POU class 4 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Ruffle Membrane Cell Projection	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Signal Transduction Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Axonogenesis Axon Guidance Heart Development Sensory Perception Of Sound Cell Differentiation Neuron Differentiation Estrogen Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Cellular Response To Insulin Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Axon Extension Neuromuscular Process Controlling Balance Regulation Of DNA-binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Adipose Tissue Development Dorsal Root Ganglion Development Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Asthma ( 29273806 31959851) Body mass index ( 28552196) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Inflammatory bowel disease ( 23128233) Physiological traits ( 31902109) Systolic blood pressure ( 30578418) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 23666239 23666240 28604728 28604732)	Malaria ( 31844061) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: ADAM12 COL8A1 CREB5 EFEMP2 FHL2 HOXA1 KLHL38 KRTAP5-11 NUTF2 OTX1 POU4F2 RAF1 RIN3 TESK1 TNS2 VENTX ZDHHC17	77 interacting genes: ADAMTSL4 ALPP CCN3 CD46 CERCAM CHIC2 CHRD CHRDL2 COL8A1 CYP21A2 CYSRT1 DLX3 ESR1 FAM86C1P GRN HDHD3 HIGD2B IGFBP6 IGFL1 INCA1 KPRP KRT31 KRT35 KRT38 KRT83 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE1F LCE2C LCE5A LCN2 LGALS13 LHX2 LYPD2 MMADHC NFKBID NOTO PCSK5 PLSCR2 RBP3 RBPMS RGS19 SPRY4 TGFB1 TRIM42 VWC2
Entrez ID		81848	5458
HPRD ID		10466	00220
Ensembl ID		ENSG00000187678	ENSG00000151615
Uniprot IDs		A0A0C4DFS6 Q9C004	Q12837
PDB IDs		3BUN
Enriched GO Terms of Interacting Partners?			Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Keratinization Protein Binding Cytosol Structural Constituent Of Skin Epidermis Identical Protein Binding
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