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CCNL2 and DYRK1A
Number of citations of the paper that reports this interaction (PMID
14623875
)
20
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vivo, in vitro)
CCNL2
DYRK1A
Gene Name
cyclin L2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Nuclear Speck
Cell Junction
Intracellular Membrane-bounded Organelle
Nucleus
Nucleoplasm
Nuclear Speck
Ribonucleoprotein Complex
Molecular Function
Protein Kinase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein Self-association
Tau Protein Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
RNA Processing
Mitotic Cell Cycle
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Protein Phosphorylation
Nervous System Development
Circadian Rhythm
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Autophosphorylation
Positive Regulation Of Protein Deacetylation
Pathways
G0 and Early G1
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Drugs
Diseases
GWAS
HIV-1 replication (
21364930
)
Metabolic syndrome (
20694148
)
Protein-Protein Interactions
6 interactors:
CDK11B
DYRK1A
POLR2A
RUNDC3A
SRSF2
SRSF7
26 interactors:
AMPH
APP
CCNL2
CLASRP
CREB1
FOXO1
GLI1
HIST1H2BB
HIST1H3A
HIST1H4A
LATS2
LIN52
LZTS2
PHYHIP
PRD
RB1
RBL1
SF3B1
SNCA
SRSF1
SRSF4
SRSF5
TROAP
YWHAB
YWHAE
YWHAG
Entrez ID
81669
1859
HPRD ID
10815
09018
Ensembl ID
ENSG00000221978
ENSG00000157540
Uniprot IDs
Q96S94
F8WAP0
Q13627
PDB IDs
2VX3
2WO6
3ANQ
3ANR
4AZE
Enriched GO Terms of Interacting Partners
?
Regulation Of MRNA Processing
Regulation Of RNA Splicing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Termination Of RNA Polymerase II Transcription
RNA Splicing
Regulation Of Nitrogen Compound Metabolic Process
MRNA Processing
Regulation Of MRNA Splicing, Via Spliceosome
MRNA Export From Nucleus
DNA-templated Transcription, Termination
RNA Export From Nucleus
MRNA 3'-end Processing
MRNA Metabolic Process
RNA Processing
RNA 3'-end Processing
Nuclear Export
MRNA Transport
Transcription, RNA-templated
RNA Transport
RNA Localization
Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Nucleocytoplasmic Transport
Nuclear Transport
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Guanylate Cyclase Activity
Positive Regulation Of CGMP Biosynthetic Process
Negative Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of CGMP Metabolic Process
Negative Regulation Of RNA Splicing
Regulation Of CGMP Biosynthetic Process
Negative Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Deacetylation
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Regulation Of CGMP Metabolic Process
7-methylguanosine MRNA Capping
PiRNA Metabolic Process
Positive Regulation Of RNA Splicing
7-methylguanosine RNA Capping
Transcription-coupled Nucleotide-excision Repair
Regulation Of Signal Transduction By P53 Class Mediator
Peptidyl-threonine Phosphorylation
Positive Regulation Of Viral Transcription
Cytoplasmic Transport
Positive Regulation Of Lyase Activity
Regulation Of Protein Deacetylation
Mitotic Cell Cycle
Gene Expression
Negative Regulation Of Cellular Metabolic Process
Mitotic Cell Cycle
Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Processing
MRNA 3'-end Processing
Cellular Localization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Establishment Of Localization In Cell
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Hippo Signaling
Regulation Of Phosphorylation
Cellular Nitrogen Compound Metabolic Process
MRNA Processing
Negative Regulation Of Gene Expression
RNA 3'-end Processing
RNA Metabolic Process
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Nuclear Export
Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Termination Of RNA Polymerase II Transcription
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Dephosphorylation
MRNA Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Transcription From RNA Polymerase II Promoter
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Protein Metabolic Process
RNA Splicing
Response To Growth Factor
Positive Regulation Of Mitochondrion Organization
Regulation Of Cell Cycle
Regulation Of Protein Metabolic Process
Cellular Macromolecular Complex Assembly
DNA Replication-dependent Nucleosome Assembly
Cellular Response To Fibroblast Growth Factor Stimulus
Negative Regulation Of Biosynthetic Process
Apoptotic Process
Cell Cycle
Negative Regulation Of Wnt Signaling Pathway
Tagcloud
?
abolished
aimed
alteration
caused
colony
direct
explore
finding
fluorescent
hcc
hepatocellular
hepg2
mir
modulated
nfat
nfib
oncogene
overexpression
p53
propose
regulated
reporter
suggests
suppresses
syndrome
target
targeting
tumorigenesis
wild
Tagcloud (Difference)
?
abolished
aimed
alteration
caused
colony
direct
explore
finding
fluorescent
hcc
hepatocellular
hepg2
mir
modulated
nfat
nfib
oncogene
overexpression
p53
propose
regulated
reporter
suggests
suppresses
syndrome
target
targeting
tumorigenesis
wild
Tagcloud (Intersection)
?