FFAR3 and LTC4S

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FFAR3	LTC4S
Name		free fatty acid receptor 3	leukotriene C4 synthase
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lipid Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Transferase Activity Lyase Activity Identical Protein Binding
	Biological Process	Immune System Process Mucosal Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Norepinephrine Secretion Positive Regulation Of Chemokine Production Negative Regulation Of Blood Pressure Regulation Of Insulin Receptor Signaling Pathway Regulation Of Hormone Biosynthetic Process Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion	Lipid Metabolic Process Leukotriene Metabolic Process Leukotriene Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Cellular Oxidant Detoxification
Pathways		G alpha (q) signalling events Free fatty acid receptors	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Drugs		None	Glutathione Azelastine
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		13 interacting genes: CD79A COMT CTXN3 EFNA5 LAT LTC4S SERINC1 SLC41A1 TEX264 TOMM6 TREX1 UNC93B1 YIPF1	12 interacting genes: ALOX5 ALOX5AP CD79A CREB3L1 EBP FFAR3 FXYD3 GPR152 GPR42 MGST1 SLC7A14 TMEM52B
Entrez ID		2865	4056
HPRD ID		04823	02004
Ensembl ID		ENSG00000185897	ENSG00000213316
Uniprot IDs		A0A0K0PUW7 O14843	Q16873
PDB IDs		8J20 8J21	2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D 9G0U 9G0V 9G14 9G1T
GO Terms Enriched among Interactors		T Cell Antigen Processing And Presentation Membrane Adaptive Immune Response Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Norepinephrine Secretion Catechol O-methyltransferase Activity Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Endoplasmic Reticulum Membrane Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System	Leukotriene Production Involved In Inflammatory Response Arachidonate Metabolite Production Involved In Inflammatory Response Membrane Production Of Molecular Mediator Involved In Inflammatory Response Leukotriene Biosynthetic Process Glutathione Peroxidase Activity Negative Regulation Of Sprouting Angiogenesis Glutathione Transferase Activity Leukotriene Metabolic Process Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Negative Regulation Of Response To Endoplasmic Reticulum Stress Icosanoid Biosynthetic Process Endoplasmic Reticulum Membrane Cellular Response To Lipid Hydroperoxide Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Sprouting Angiogenesis Nuclear Membrane Leukotriene A4 Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity Cellular Oxidant Detoxification Regulation Of Response To Endoplasmic Reticulum Stress Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell IgM B Cell Receptor Complex Response To Lipid Hydroperoxide Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity Extracellular Matrix Constituent Secretion Icosanoid Metabolic Process G Protein-coupled Receptor Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Cellular Detoxification B Cell Receptor Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Endoplasmic Reticulum Leukotriene-C4 Synthase Activity Small Molecule Biosynthetic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Arachidonate Binding Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity