FIP1L1 and WWOX

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FIP1L1	WWOX
Description		factor interacting with PAPOLA and CPSF1	WW domain containing oxidoreductase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex	Nucleus Cytoplasm Mitochondrion Lysosome Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Binding Protein Binding	Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding Identical Protein Binding
	Biological Process	MRNA Processing	Osteoblast Differentiation Apoptotic Process Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) DNA methylation (variation) ( 23725790) Lymphocyte count ( 32888494) Red blood cell count ( 28453575) Serum VEGFR2 concentration ( 25411163) Subcortical volume (MOSTest) ( 32665545)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Age at first sexual intercourse ( 34211149) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa ( 23568457) Bipolar disorder (body mass index interaction) ( 24322204) Brain morphology (MOSTest) ( 32665545) Brain volume in infants (white matter) ( 28763065) Cardiac structure and function ( 19584346) Clozapine-induced cytotoxicity ( 25656473) Colorectal cancer ( 30529582 29228715) Daytime sleep phenotypes ( 27126917) Diffusing capacity of carbon monoxide ( 30694715) Early-onset Parkinson's disease ( 28256260) Eosinophil count ( 32888494) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Familial squamous cell lung carcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) ghrelin levels ( 33852427) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip shape (DXA scan) ( 30320955) Idiopathic dilated cardiomyopathy ( 29495422) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Major depressive disorder x sex interaction ( 34099189) Metabolite levels ( 23823483) Metabolite levels (5-HIAA) ( 23319000) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Obesity ( 21552555) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Parkinson's disease progression (cognitive) ( 33958783) Peak expiratory flow ( 30804560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Radiation response ( 20923822) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum thyroid-stimulating hormone levels ( 25436638) Serum uric acid levels in response to allopurinol in gout ( 25676789) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Systemic juvenile idiopathic arthritis ( 27927641) Triglyceride levels ( 34074324) Type 2 diabetes ( 22158537) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		31 interacting genes: APP CEBPA CPSF4 CSNK2A1 GOLGA2 HMGB1 LIG4 MIR128-2 MIR15B MIR16-2 MIR19A MIR19B1 MIR205 MIR221 MIR34A MIR34B MIR9-3 MIR92A1 MIR92A2 MIRLET7B MIRLET7G MIRLET7I NAA10 OGT PAPOLA PRMT2 PRMT6 SGTA SRPK2 WWOX ZMYND19	115 interacting genes: ABHD11 ABI2 ACAT2 ACTMAP ACY1 ADRA2C ANAPC11 ANXA11 APBB2 ATOSB C10orf55 C11orf87 CCDC24 CEACAM6 CLNK CNNM3 CPSF2 CPSF6 CPSF7 CREB5 CSNK2B CTAG1A CTAG1B CTDSP1 DAZAP2 DMRT3 ENKD1 ERBB4 EZR FAM222B FEM1A FIP1L1 FOXD4L1 FOXI1 FRS3 GCM2 GEM GLIS2 GNE HNRNPK HOXA1 HOXC8 HSPB2 HSPB2-C11orf52 HYAL2 IFIT2 INCA1 KLHDC7B KLHL38 KRT3 KRT34 KRT75 KRTAP11-1 LASP1 LATS1 LITAF LMO3 MAPK8 MED25 MKRN3 MYG1 MYOZ1 MYOZ2 NEDD9 NUDT21 OLIG3 OTX1 PATL1 PATZ1 PAX9 PBX4 PEF1 PITX2 PLAC8 PLEKHN1 PLSCR3 PSMB8 RAMAC RUSC1 SAXO1 SAXO4 SCAMP3 SEC23IP SF3B3 SH2D4A SHC3 SLC15A2 SMAD4 SMR3A SNRPC SPMIP9 SRC TCERG1 TCHP TEKT3 TFAP2C TFG TNK2 TP53 TP73 TRIM69 TSGA10IP UBB UFSP1 VENTX VEZF1 VPS37C WDR33 WIPF2 YPEL3 ZBTB32 ZIC1 ZNF135 ZNF414 ZNF581
Entrez ID		81608	51741
HPRD ID		09646	05501
Ensembl ID		ENSG00000145216	ENSG00000186153
Uniprot IDs		A0A994J3I9 A0A994J3J1 A0A994J3K1 A0A994J3K5 A0A994J3L5 A0A994J3M0 A0A994J3P6 A0A994J3Q0 A0A994J3Q5 A0A994J3R0 A0A994J3R5 A0A994J3S0 A0A994J3S6 A0A994J3T5 A0A994J438 A0A994J442 A0A994J453 A0A994J458 A0A994J464 A0A994J469 A0A994J474 A0A994J6B4 A0A994J6C6 A0A994J6D3 A0A994J6D6 A0A994J6E0 A0A994J6E2 A0A994J6N5 A0A994J6P0 A0A994J6Q5 A0A994J6R0 H0Y8P7 Q6UN15	A0A411HBC7 Q9NZC7
PDB IDs		7K95 7ZY4 7ZYH	1WMV
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Vasculature Development MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Inflammatory Response MRNA 3'-UTR Binding Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Defense Response Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Gene Expression Regulation Of Cell Motility Regulation Of Defense Response	MRNA Cleavage And Polyadenylation Specificity Factor Complex Protein Binding Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific MRNA Alternative Polyadenylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA 3'-end Processing MRNA Cleavage Factor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Chromatin DNA-binding Transcription Factor Activity MRNA Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Heterotetramerization Skeletal Muscle Fiber Adaptation RNA 3'-end Processing Positive Regulation Of Biosynthetic Process Anatomical Structure Morphogenesis Keratin Filament Histone Deacetylase Regulator Activity Protein Tetramerization Positive Regulation Of Protein Monoubiquitination FATZ Binding Regulation Of Primary Metabolic Process WW Domain Binding Axonemal A Tubule Inner Sheath DNA Binding Regulation Of Protein Monoubiquitination Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Growth Protein Heterooligomerization Receptor Tyrosine Kinase Binding
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