FIP1L1 and PRMT2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid, two hybrid)

		FIP1L1	PRMT2
Description		factor interacting with PAPOLA and CPSF1	protein arginine methyltransferase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding	Transcription Coactivator Activity Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Nuclear Estrogen Receptor Binding Nuclear Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Thyroid Hormone Receptor Binding Nuclear Androgen Receptor Binding Histone H3R8 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	MRNA Processing	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Developmental Cell Growth Negative Regulation Of Inflammatory Response Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) DNA methylation (variation) ( 23725790) Lymphocyte count ( 32888494) Red blood cell count ( 28453575) Serum VEGFR2 concentration ( 25411163) Subcortical volume (MOSTest) ( 32665545)	Diverticular disease ( 30177863)
Interacting Genes		31 interacting genes: APP CEBPA CPSF4 CSNK2A1 GOLGA2 HMGB1 LIG4 MIR128-2 MIR15B MIR16-2 MIR19A MIR19B1 MIR205 MIR221 MIR34A MIR34B MIR9-3 MIR92A1 MIR92A2 MIRLET7B MIRLET7G MIRLET7I NAA10 OGT PAPOLA PRMT2 PRMT6 SGTA SRPK2 WWOX ZMYND19	37 interacting genes: BAG6 CBLB CHEK2 CPSF7 DAZAP1 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 IQSEC2 KDM6B MYO6 NCOA1 NCOA6 PGR PRMT8 PRRC2A PSMB3 R3HDM1 RB1 RBM12 RBM22 RIPK2 RXRA SHANK1 SHANK3 SHTN1 SPAG8 THRB WASL WBP11 YLPM1 ZFP36 ZNF341 ZSWIM8
Entrez ID		81608	3275
HPRD ID		09646	09060
Ensembl ID		ENSG00000145216	ENSG00000160310
Uniprot IDs		A0A994J3I9 A0A994J3J1 A0A994J3K1 A0A994J3K5 A0A994J3L5 A0A994J3M0 A0A994J3P6 A0A994J3Q0 A0A994J3Q5 A0A994J3R0 A0A994J3R5 A0A994J3S0 A0A994J3S6 A0A994J3T5 A0A994J438 A0A994J442 A0A994J453 A0A994J458 A0A994J464 A0A994J469 A0A994J474 A0A994J6B4 A0A994J6C6 A0A994J6D3 A0A994J6D6 A0A994J6E0 A0A994J6E2 A0A994J6N5 A0A994J6P0 A0A994J6Q5 A0A994J6R0 H0Y8P7 Q6UN15	A0A0S2Z3N3 P55345
PDB IDs		7K95 7ZY4 7ZYH	1X2P
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Vasculature Development MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Inflammatory Response MRNA 3'-UTR Binding Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Defense Response Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Gene Expression Regulation Of Cell Motility Regulation Of Defense Response	Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Nucleus Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process MRNA Metabolic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Estrogen Response Element Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Dendritic Spine Morphogenesis Nucleic Acid Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Activity Synaptic Receptor Adaptor Activity Regulation Of Transcription By RNA Polymerase II Steroid Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Dendritic Spine Organization RNA Binding Nuclear Estrogen Receptor Binding Neuron Projection Organization Postsynapse Organization Regulation Of Female Receptivity Female Mating Behavior MRNA Transcription By RNA Polymerase II
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